Telomeres and Telomerase: The Means to the End (Nobel Lecture)

被引：172

作者：

Blackburn, Elizabeth H. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 41期

关键词：

DNA; Nobel lecture; telomerase; telomeres; TERMINAL TRANSFERASE; TETRAHYMENA RDNA; SEQUENCE; DNA; HEXANUCLEOTIDE; LENGTH; GENES; LIFE; RNA;

D O I：

10.1002/anie.201002387

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Secrets revealed: The Nobel Prize for Medicine 2009 was awarded for the solution to one of the greatest mysteries of biology: how are chromosomes copied upon cell division and protected from degradation? The answer can be found at the ends of the chromosomes-the telomeres- and in the enzyme that forms them-telomerase. The laureates describe the events leading to the discovery first-hand. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7405 / 7421

页数：17

共 30 条

[1] GROWTH OF CHROMOSOME ENDS IN MULTIPLYING TRYPANOSOMES [J].

BERNARDS, A ;

MICHELS, PAM ;

LINCKE, CR ;

BORST, P .

NATURE, 1983, 303 (5918) :592-597

[2]

BLACKBURN E, 1983, COLD SPRING HARBOR S

[3] TELOMERES AND THEIR SYNTHESIS [J].

BLACKBURN, EH .

SCIENCE, 1990, 249 (4968) :489-490

[4] TANDEMLY REPEATED SEQUENCE AT TERMINI OF EXTRACHROMOSOMAL RIBOSOMAL-RNA GENES IN TETRAHYMENA [J].

BLACKBURN, EH ;

GALL, JG .

JOURNAL OF MOLECULAR BIOLOGY, 1978, 120 (01) :33-53

[5] THE MOLECULAR-STRUCTURE OF CENTROMERES AND TELOMERES [J].

BLACKBURN, EH ;

SZOSTAK, JW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1984, 53 :163-194

[6] Switching and signaling at the telomere [J].

Blackburn, EH .

CELL, 2001, 106 (06) :661-673

[7] INVERTED TERMINAL REPEATS ARE ADDED TO GENES DURING MACRONUCLEAR DEVELOPMENT IN OXYTRICHA-NOVA [J].

BOSWELL, RE ;

KLOBUTCHER, LA ;

PRESCOTT, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3255-3259

[8]

de Lange T., 2006, Telomeres, V2nd, P1

[9] AN IRREGULAR SATELLITE SEQUENCE IS FOUND AT THE TERMINI OF THE LINEAR EXTRACHROMOSOMAL RDNA IN DICTYOSTELIUM DISCOIDEUM [J].

EMERY, HS ;

WEINER, AM .

CELL, 1981, 26 (03) :411-419

[10] Dynamics of telomerase activity in response to acute psychological stress [J].

Epel, Elissa S. ;

Lin, Jue ;

Dhabhar, Firdaus S. ;

Wolkowitz, Owen M. ;

Puterman, E. ;

Karan, Lori ;

Blackburn, Elizabeth H. .

BRAIN BEHAVIOR AND IMMUNITY, 2010, 24 (04) :531-539

← 1 2 3 →