Antioxidant Activity of Tetranitrosyl Iron Complex with Thiosulfate Ligands and Its Effect on Catalytic Activity of Mitochondrial Enzymes In vitro

被引：6

作者：

Faingold, I. I. ^{[1
,2
]}

Kotelnikova, R. A. ^{[1
]}

Smolina, A., V ^{[1
]}

Poletaeva, D. A. ^{[1
]}

Soldatova, Yu, V ^{[1
]}

Pokidova, O., V ^{[1
]}

Sadkov, A. P. ^{[1
]}

Sanina, N. A. ^{[1
,2
,3
]}

Aldoshin, S. M. ^{[1
,3
]}

机构：

[1] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka, Moscow Oblast, Russia

[2] Moscow Reg State Univ, Med Chem Res & Educ Ctr, Mytischchi, Moscow Oblast, Russia

[3] Moscow MV Lomonosov State Univ, Moscow, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2019年 / 488卷 / 01期

关键词：

NITRIC-OXIDE; PATHOPHYSIOLOGY;

D O I：

10.1134/S1607672919050120

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) were studied in vitro in mouse brain homogenates. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes cytochrome c oxidase and monoamine oxidase A was studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in animal brain mitochondria in vitro.

引用

页码：342 / 345

页数：4

共 14 条

[1] Monoamine oxidase inactivation: From pathophysiology to therapeutics [J].

Bortolato, Marco ;

Chen, Kevin ;

Shih, Jean C. .

ADVANCED DRUG DELIVERY REVIEWS, 2008, 60 (13-14) :1527-1533

[2] Major depression and heart failure: Interest of monoamine oxidase inhibitors [J].

Corbineau, Sophie ;

Breton, Marie ;

Mialet-Perez, Jeanne ;

Costemale-Lacoste, Jean-Francois .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2017, 247 :1-6

[3]

DIMEO S, 1995, ARCH PHYSIOL BIOCHEM, V103, P187

[4] Biochemical mechanism of nitroglycerin action and tolerance: Is this old mystery solved? [J].

Fung, HL .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2004, 44 :67-85

[5] Free radicals and antioxidants: updating a personal view [J].

Halliwell, Barry .

NUTRITION REVIEWS, 2012, 70 (05) :257-265

[6]

Ignarro L.J., 2000, Nitric Oxide

[7]

KARYAKIN YV, 1974, CHISTYE KHIMICHESKIE

[8]

Kotel'nikova R.A., 2014, IZV AKAD NAUK K, P2375

[9] New insights on receptor-dependent and monoamine oxidase-dependent effects of serotonin in the heart [J].

Mialet-Perez, J. ;

Bianchi, P. ;

Kunduzova, O. ;

Parini, A. .

JOURNAL OF NEURAL TRANSMISSION, 2007, 114 (06) :823-827

[10] Role of nitric oxide in the biology, physiology and pathophysiology of reproduction [J].

Rosselli, M ;

Keller, PJ ;

Dubey, RK .

HUMAN REPRODUCTION UPDATE, 1998, 4 (01) :3-24

← 1 2 →