Mini-dose of thalidomide for treatment of primary myelofibrosis. Report of a case with complete reversal of bone marrow fibrosis and splenomegaly

被引:6
作者
Berrebi, A. [1 ]
Feldberg, E. [2 ]
Spivak, I [3 ]
Shvidel, L. [1 ]
机构
[1] Kaplan Med Ctr, Hematol Inst, IL-76100 Rehovot, Israel
[2] Kaplan Med Ctr, Pathol Dept, Rehovot, Israel
[3] Yoseftal Hosp, Internal Med Dept, Elat, Israel
关键词
myelofibrosis; thalidomide;
D O I
10.3324/haematol.10684
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly and bone narrow fibrosis after 30 months of the treatment
引用
收藏
页码:15 / 16
页数:2
相关论文
共 6 条
  • [1] Abgrall JF, 2006, HAEMATOLOGICA, V91, P1027
  • [2] Low-dose thalidomide ameliorates cytopenias and splenomegaly in myelofibrosis with myeloid metaplasia: A phase II trial
    Marchetti, M
    Barosi, G
    Balestri, F
    Viarengo, G
    Gentili, S
    Barulli, S
    Demory, JL
    Ilariucci, F
    Volpe, A
    Bordessoule, D
    Grossi, A
    Le Bousse-Kerdiles, MC
    Caenazzo, A
    Pecci, A
    Falcone, A
    Broccia, G
    Bendotti, C
    Bauduer, F
    Buccisano, F
    Dupriez, B
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (03) : 424 - 431
  • [3] Negligible clinical effects of thalidomide in patients with myelofibrosis with myeloid metaplasia
    Merup, M
    Kutti, J
    Birgergård, G
    Mauritzson, N
    Björkholm, M
    Markevärn, B
    Malm, C
    Westin, J
    Palmblad, J
    Samuelsson, J
    [J]. MEDICAL ONCOLOGY, 2002, 19 (02) : 79 - 86
  • [4] A phase 2 trial of combination low-dose thalidomide and prednisone for the treatment of myelofibrosis with myeloid metaplasia
    Mesa, RA
    Steensma, DP
    Pardanani, A
    Li, CY
    Elliott, M
    Kaufmann, SH
    Wiseman, G
    Gray, LA
    Schroeder, GE
    Reeder, T
    Zeldis, JB
    Tefferi, A
    [J]. BLOOD, 2003, 101 (07) : 2534 - 2541
  • [5] Survivorship and prognosis in myelofibrosis with myeloid metaplasia
    Tefferi, A
    [J]. LEUKEMIA & LYMPHOMA, 2006, 47 (03) : 379 - 380
  • [6] Thalidomide therapy for myelofibrosis with myeloid metaplasia
    Thomas, DA
    Giles, FJ
    Albitar, M
    Cortes, JE
    Verstovsek, S
    Faderl, S
    O'Brien, SM
    Garcia-Manero, G
    Keating, MJ
    Pierce, S
    Zeldis, J
    Kantarjian, HM
    [J]. CANCER, 2006, 106 (09) : 1974 - 1984