Training and extinction of passive avoidance in mice lacking monoamine oxidase A

被引：0
|
作者：
Dubrovina, NI
Popova, NK
Gilinsky, MA
Tomilenko, RA
Seif, I
机构：
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2005年 / 55卷 / 02期
关键词：
genetic knockout; passive avoidance; extinction; memory; MAO A;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The passive avoidance learning and memory trace retention in mice lacking monoamine oxidase A (MAO A) and control C3H strain were analyzed. It is shown that mice of both strains were well the passive avoidance learners. A delay of the memory trace extinction was found in lacking MAO A mice as compared with control C3H strain. Mice with a genetic MAO A knockout showed decreased amounts of transitions, rearings, looking to a dark compartment and appearing from it. These findings seem to reflect more expressed fear reaction to a dangerous compartment and increased anxiety promoting longer retention of memory trace on a high level of retrieval.
引用
收藏
页码：221 / 226
页数：6
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