Effect of hesperidin on matrix metalloproteinases and antioxidant status during nicotine-induced toxicity

被引：41

作者：

Balakrishnan, Annida ^{[1
]}

Menon, Venugopal P. ^{[1
]}

机构：

[1] Annamalai Univ, Fac Sci, Dept Biochem & Biotechnol, Annamalainagar 608002, Tamil Nadu, India

来源：

TOXICOLOGY | 2007年 / 238卷 / 2-3期

关键词：

antioxidants; Extra cellular matrix (ECM); free radicals; Ratrix metalloproteinases (MMPs); Reactive oxygen species (ROS);

D O I：

10.1016/j.tox.2007.04.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cigarette smoking has been established as a major risk factor for atherosclerosis and also for lung cancer. Nicotine is an active substance present in tobacco. We have analyzed the effect of hesperidin, a bioflavonoid on nicotine induced toxicity. Antioxidant status and expression of MMPs (Matrix metalloproteinases) were analyzed to monitor the protective effect of hesperidin against nicotine toxicity. Our result demonstrated that nicotine significantly up regulates the expression of MMPs and depletes the antioxidant status. On treatment with hesperidin we found the down regulation of expression of MMPs and enhancement in antioxidant status. Hence it could be developed as a drug against tobacco related disease in near future. (c) 2007 Published by Elsevier Ireland Ltd.

引用

页码：90 / 98

页数：9

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