Calcium phosphate/block copolymer hybrid porous nanospheres: Preparation and application in drug delivery

被引：19
作者：
Wang, Ke-Wei [1 ]
Zhu, Ying-Jie [1 ]
Chen, Feng [1 ]
Cao, Shao-Wen [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
来源：
MATERIALS LETTERS | 2010年 / 64卷 / 21期
基金：
中国国家自然科学基金;
关键词：
Calcium phosphate; Block copolymer; Nanosphere; Drug delivery; IN-VITRO; NANOCOMPOSITE PARTICLES; NANOPARTICLES; HYDROXYAPATITE; CARRIERS; GROWTH; CELLS;
D O I：
10.1016/j.matlet.2010.07.060
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Calcium phosphate (CaP)/block copolymer hybrid porous nanospheres were synthesized by a simple solution method using CaCl2 and (NH4)(2)HPO4 in the presence of a block copolymer at room temperature. X-ray diffraction showed that the sample consisted of amorphous calcium phosphate (ACP). The BET specific surface area and the pore size distribution of the CaP/PLLA-mPEG hybrid porous nanospheres were also characterized. The as-prepared CaP/PLLA-mPEG hybrid porous nanospheres were explored as drug carriers, and showed a high ibuprofen loading capacity and in vitro prolonged drug release behavior in a simulated body fluid. These CaP/block copolymer hybrid porous nanospheres exhibit a great potential for application in drug delivery. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：2299 / 2301
页数：3
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