Pro inflammatory stimuli enhance the immunosuppressive functions of adipose mesenchymal stem cells derived exosomes

被引：201

作者：

Domenis, Rossana ^{[1
]}

Cifu, Adriana ^{[1
]}

Quaglia, Sara ^{[1
]}

Pistis, Cinzia ^{[1
]}

Moretti, Massimo ^{[2
]}

Vicario, Annalisa ^{[2
]}

Parodi, Pier Camillo ^{[4
]}

Fabris, Martina ^{[1
,3
]}

Niazi, Kayvan R. ^{[5
]}

Soon-Shiong, Patrick ^{[5
]}

Curcio, Francesco ^{[1
,3
]}

机构：

[1] Univ Udine, Dipartimento Area Med, I-33100 Udine, Italy

[2] VivaBioCell SpA, I-33100 Udine, Italy

[3] Azienda Sanit Univ Integrata Udine, Ist Patol Clin, I-33100 Udine, Italy

[4] Azienda Sanit Univ Integrata Udine, Clin Chirurg Plast, I-33100 Udine, Italy

[5] NantBioSci Inc Culver City, Culver City, CA 90232 USA

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

EXTRACELLULAR VESICLES; INTERFERON-GAMMA; INDUCTION; ACTIVATION;

D O I：

10.1038/s41598-018-31707-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The predominant mechanism by which adipose mesenchymal stem cells (AMSCs) participate to tissue repair is through a paracrine activity and their communication with the inflammatory microenvironment is essential part of this process. This hypothesis has been strengthened by the recent discovery that stem cells release not only soluble factors but also extracellular vesicles, which elicit similar biological activity to the stem cells themselves. We demonstrated that the treatment with inflammatory cytokines increases the immunosuppressive and anti-inflammatory potential of AMSCs-derived exosomes, which acquire the ability to shift macrophages from M1 to M2 phenotype by shuttling miRNA regulating macrophages polarization. This suggests that the immunomodulatory properties of AMSCs-derived exosomes may be not constitutive, but are instead induced by the inflammatory microenvironment.

引用

页数：11

共 42 条

[21] Tumor necrosis factor-α-activated mesenchymal stem cells promote endothelial progenitor cell homing and angiogenesis [J].