Lineage Relationship Analysis of RORγt+ Innate Lymphoid Cells

被引：422

作者：

Sawa, Shinichiro ^{[1
,2
]}

Cherrier, Marie ^{[1
,2
]}

Lochner, Matthias ^{[1
,2
,3
,4
]}

Satoh-Takayama, Naoko ^{[5
,6
]}

Fehling, Hans Joerg ^{[7
]}

Langa, Francina

Di Santo, James P. ^{[5
,6
]}

Eberl, Gerard ^{[1
,2
]}

机构：

[1] Inst Pasteur, Lymphoid Tissue Dev Unit, F-75724 Paris, France

[2] CNRS, URA1961, F-75724 Paris, France

[3] Hannover Med Sch, Ctr Expt & Clin Infect Res, TWINCORE, Inst Infect Immunol, D-3000 Hannover, Germany

[4] Helmholtz Ctr Infect Res, Hannover, Germany

[5] Inst Pasteur, Innate Immun Unit, F-75724 Paris, France

[6] INSERM, U668, F-75724 Paris, France

[7] Univ Clin Ulm, Inst Immunol, Ulm, Germany

来源：

SCIENCE | 2010年 / 330卷 / 6004期

关键词：

ROR-GAMMA-T; TISSUE-INDUCER CELLS; NATURAL-KILLER-CELLS; PROINFLAMMATORY IL-17(+); NKP46(+) CELLS; HELPER-CELLS; IN-VIVO; DIFFERENTIATION; IMMUNITY; ORGANOGENESIS;

D O I：

10.1126/science.1194597

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Lymphoid tissue-inducer (LTi) cells initiate the development of lymphoid tissues through the activation of local stromal cells in a process similar to inflammation. LTi cells express the nuclear hormone receptor ROR gamma t, which also directs the expression of the proinflammatory cytokine interleukin-17 in T cells. We show here that LTi cells are part of a larger family of proinflammatory ROR gamma t(+) innate lymphoid cells (ILCs) that differentiate from distinct fetal liver ROR gamma t(+) precursors. The fate of ROR gamma t(+) ILCs is determined by mouse age, and after birth, favors the generation of cells involved in intestinal homeostasis and defense. Contrary to ROR gamma t(+) T cells, however, ROR gamma t(+) ILCs develop in the absence of microbiota. Our study indicates that ROR gamma t(+) ILCs evolve to preempt intestinal colonization by microbial symbionts.

引用

页码：665 / 669

页数：5

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