Multiagent chemotherapy including IrIVA regimen and maintenance therapy in the treatment of desmoplastic small round cell tumor

被引：10

作者：

Ferrari, Andrea ^{[1
]}

Bergamaschi, Luca ^{[1
]}

Chiaravalli, Stefano ^{[1
]}

Pecori, Emilia ^{[2
]}

Diletto, Barbara ^{[2
]}

Alessandro, Ombretta ^{[2
]}

Giandini, Tommaso ^{[3
]}

Virginia, Livellara ^{[1
]}

Sironi, Giovanna ^{[1
]}

Casanova, Michela ^{[1
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Pediat Radiotherapy Unit, Milan, Italy

[3] Fdn IRCCS Ist Nazl Tumori, Med Phys Unit, Milan, Italy

来源：

TUMORI JOURNAL | 2022年 / 108卷 / 01期

关键词：

Desmoplastic small round cell tumor; chemotherapy; IrIVA; irinotecan; maintenance therapy; vinorelbine; MODULATED RADIATION-THERAPY; MULTIMODAL TREATMENT; SURVIVAL; SURGERY;

D O I：

10.1177/0300891621995250

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study reports the treatment feasibility and efficacy of a novel multiagent intensive treatment program for young patients with desmoplastic small round cell tumor. This small series includes three patients and should be seen as a first suggestion of integration of the dose density and the maintenance chemotherapy concept. The IrIVA regimen (irinotecan, ifosfamide, vincristine, and actinomycin-D) is added-used at a short interval between chemotherapy administrations-at more classic intensive ifosfamide-based regimens. The vinorelbine and low-dose oral cyclophosphamide maintenance therapy is added at the end of conventional chemotherapy to achieve an antiangiogenic effect.

引用

页码：93 / 97

页数：5