Multiagent chemotherapy including IrIVA regimen and maintenance therapy in the treatment of desmoplastic small round cell tumor

被引：10

作者：

Ferrari, Andrea ^{[1
]}

Bergamaschi, Luca ^{[1
]}

Chiaravalli, Stefano ^{[1
]}

Pecori, Emilia ^{[2
]}

Diletto, Barbara ^{[2
]}

Alessandro, Ombretta ^{[2
]}

Giandini, Tommaso ^{[3
]}

Virginia, Livellara ^{[1
]}

Sironi, Giovanna ^{[1
]}

Casanova, Michela ^{[1
]}

机构：

[1] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy

[2] Fdn IRCCS Ist Nazl Tumori, Pediat Radiotherapy Unit, Milan, Italy

[3] Fdn IRCCS Ist Nazl Tumori, Med Phys Unit, Milan, Italy

来源：

TUMORI JOURNAL | 2022年 / 108卷 / 01期

关键词：

Desmoplastic small round cell tumor; chemotherapy; IrIVA; irinotecan; maintenance therapy; vinorelbine; MODULATED RADIATION-THERAPY; MULTIMODAL TREATMENT; SURVIVAL; SURGERY;

D O I：

10.1177/0300891621995250

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study reports the treatment feasibility and efficacy of a novel multiagent intensive treatment program for young patients with desmoplastic small round cell tumor. This small series includes three patients and should be seen as a first suggestion of integration of the dose density and the maintenance chemotherapy concept. The IrIVA regimen (irinotecan, ifosfamide, vincristine, and actinomycin-D) is added-used at a short interval between chemotherapy administrations-at more classic intensive ifosfamide-based regimens. The vinorelbine and low-dose oral cyclophosphamide maintenance therapy is added at the end of conventional chemotherapy to achieve an antiangiogenic effect.

引用

页码：93 / 97

页数：5

共 21 条

[1] Sequential intensified chemotherapy with stem cell rescue for children and adolescents with desmoplastic small round-cell tumor [J].

Bisogno, G. ;

Ferrari, A. ;

Rosolen, A. ;

Alaggio, R. ;

Scarzello, G. ;

Garaventa, A. ;

Arcamone, G. ;

Carli, M. .

BONE MARROW TRANSPLANTATION, 2010, 45 (05) :907-911

[2] Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial [J].

Bisogno, Gianni ;

De Salvo, Gian Luca ;

Bergeron, Christophe ;

Gallego Melcon, Soledad ;

Merks, Johannes H. ;

Kelsey, Anna ;

Martelli, Helene ;

Minard-Colin, Veronique ;

Orbach, Daniel ;

Glosli, Heidi ;

Chisholm, Julia ;

Casanova, Michela ;

Zanetti, Ilaria ;

Devalck, Christine ;

Ben-Arush, Myriam ;

Mudry, Peter ;

Ferman, Sima ;

Jenney, Meriel ;

Ferrari, Andrea .

LANCET ONCOLOGY, 2019, 20 (11) :1566-1575

[3] Reduced Toxicity With Intensity Modulated Radiation Therapy (IMRT) for Desmoplastic Small Round Cell Tumor (DSRCT): An Update on the Whole Abdominopelvic Radiation Therapy (WAP-RT) Experience [J].

Desai, Neil B. ;

Stein, Nicholas F. ;

LaQuaglia, Michael P. ;

Alektiar, Kaled M. ;

Kushner, Brian H. ;

Modak, Shakeel ;

Magnan, Heather M. ;

Goodman, Karyn ;

Wolden, Suzanne L. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2013, 85 (01) :E67-E72

[4] Response to vinorelbine and low-dose cyclophosphamide chemotherapy in two patients with desmoplastic small round cell tumor [J].

Ferrari, Andrea ;

Grosso, Federica ;

Stacchiotti, Silvia ;

Meazza, Cristina ;

Zaffignani, Elena ;

Marchiano, Alfonso ;

Casanova, Michela .

PEDIATRIC BLOOD & CANCER, 2007, 49 (06) :864-866

[5] A home run for rhabdomyosarcoma after 30 years: What now? [J].

Ferrari, Andrea ;

Gasparini, Patrizia ;

Casanova, Michela .

TUMORI JOURNAL, 2020, 106 (01) :5-11

[6] Pazopanib in advanced desmoplastic small round cell tumours: a multi-institutional experience [J].

Frezza, Anna Maria ;

Benson, Charlotte ;

Judson, Ian R. ;

Litiere, Saskia ;

Marreaud, Sandrine ;

Sleijfer, Stefan ;

Blay, Jean-Yves ;

Dewji, Raz ;

Fisher, Cyril ;

van der Graaf, Winette ;

Hayward, Larry .

CLINICAL SARCOMA RESEARCH, 2014, 4

[7] Complete Cytoreduction and HIPEC Improves Survival in Desmoplastic Small Round Cell Tumor [J].

Hayes-Jordan, Andrea ;

Green, Holly L. ;

Lin, Heather ;

Owusu-Agyemang, Pascal ;

Fitzgerald, Nancy ;

Arunkumar, Radha ;

Mejia, Rodrigo ;

Okhuysen-Cawley, Regina ;

Mauricio, Rizalina ;

Fournier, Keith ;

Ludwig, Joseph ;

Anderson, Peter .

ANNALS OF SURGICAL ONCOLOGY, 2014, 21 (01) :220-224

[8] Abdominal desmoplastic small round cell tumor without extraperitoneal metastases: Is there a benefit for HIPEC after macroscopically complete cytoreductive surgery? [J].

Honore, C. ;

Atallah, V. ;

Mir, O. ;

Orbach, D. ;

Ferron, G. ;

LePechoux, C. ;

Delhorme, J. B. ;

Philippe-Chomette, P. ;

Sarnacki, S. ;

Msika, S. ;

Terrier, P. ;

Glehen, O. ;

Martelli, H. ;

Minard-Colin, V. ;

Bertucci, F. ;

Blay, J. Y. ;

Bonvalot, S. ;

Elias, D. ;

LeCesne, A. ;

Sargos, P. .

PLOS ONE, 2017, 12 (02)

[9] Abdominal Desmoplastic Small Round Cell Tumor: Multimodal Treatment Combining Chemotherapy, Surgery, and Radiotherapy is the Best Option [J].

Honore, Charles ;

Amroun, Koceila ;

Vilcot, Laurence ;

Mir, Olivier ;

Domont, Julien ;

Terrier, Philippe ;

Le Cesne, Axel ;

Le Pechoux, Cecile ;

Bonvalot, Sylvie .

ANNALS OF SURGICAL ONCOLOGY, 2015, 22 (04) :1073-1079

[10] Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series [J].

Italiano, Antoine ;

Kind, Michele ;

Cioffi, Angela ;

Maki, Robert G. ;

Bui, Binh .

TARGETED ONCOLOGY, 2013, 8 (03) :211-213

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