Preparation and characterization of core-shell type Ag@SiO2 nanoparticles for photodynamic cancer therapy

被引：25

作者：

Dhanalekshmi, K. I. ^{[1
]}

Magesan, P. ^{[2
]}

Sangeetha, K. ^{[3
]}

Zhang, Xiang ^{[1
]}

Jayamoorthy, K. ^{[4
]}

Srinivasan, N. ^{[5
]}

机构：

[1] Beijing Inst Technol, Sch Mech Engn, Beijing 100081, Peoples R China

[2] Bharath Univ, Bharath Inst Higher Educ & Res, Dept Chem, Chennai 600073, Tamil Nadu, India

[3] Bharath Univ, Bharath Inst Higher Educ & Res, Dept IBT, Chennai 600073, Tamil Nadu, India

[4] St Josephs Coll Engn, Dept Chem, Chennai, Tamil Nadu, India

[5] Pachiyappas Coll Men, Dept Chem, Kanchipuram 631501, Tamil Nadu, India

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2019年 / 28卷

关键词：

Photodynamic therapy; Photohemolysis; Core-shell nanoparticles; Stober's method; SURFACE-PLASMON RESONANCE; PHOTOSENSITIZERS; OXYGEN; SPECTROSCOPY; APOPTOSIS; CELLS;

D O I：

10.1016/j.pdpdt.2019.10.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With recent scientific developments, Photodynamic therapy (PDT) offers the promisie to become incorporated into the mainstream of cancer therapy. Noble metal based nano-PDT is increasing due to its advantages in the field of biomedicine. In this study, noble metal based Ag@SiO2 core-shell nanoparticles were synthesized and to confirm the core-shell structure they were characterized by UV-vis, XRD, FTIR, TEM, and EDX. Our data confirm that core-shell type Ag@SiO2 nanoparticles maintain its ability to kill cancer cells upon light irradiation. This shows that SiO2 shell may not only prevent aggregation but it also may enhance the photodynamic activity of Ag nanoparticles.

引用

页码：324 / 329

页数：6

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