Oral Ketamine for the Rapid Treatment of Depression and Anxiety in Patients Receiving Hospice Care

被引：86

作者：

Irwin, Scott A. ^{[1
]}

Iglewicz, Alana ^{[2
]}

机构：

[1] San Diego Hosp, Inst Palliat Med, San Diego, CA 92103 USA

[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

来源：

JOURNAL OF PALLIATIVE MEDICINE | 2010年 / 13卷 / 07期

关键词：

LOW-DOSE KETAMINE; RESISTANT MAJOR DEPRESSION; STAR-ASTERISK-D; CANCER PAIN; INTRAVENOUS KETAMINE; BREAKTHROUGH PAIN; MORPHINE THERAPY; DOUBLE-BLIND; ADJUVANT; MANAGEMENT;

D O I：

10.1089/jpm.2010.9808

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Depression is prevalent and undertreated in patients receiving hospice care. Standard antidepressants do not work rapidly or often enough to benefit most of these patients. Here, two cases are reported in which a single oral dose of ketamine provided rapid and moderately sustained symptom relief for both depression and anxiety. In addition, no adverse effects were noted. Further investigation with randomized, controlled clinical trials is necessary to firmly establish the effectiveness of oral ketamine for the treatment of depression and anxiety in patients receiving hospice care. Ketamine may be a promising safe, effective, and cost-effective rapid treatment for depression and anxiety in this population.

引用

页码：903 / 908

页数：6

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