Androgens, Body Composition, and Their Metabolism Based on Sex

被引:15
作者
Giagulli, Vito Angelo [1 ]
Castellana, Marco [2 ]
Pelusi, Carla [3 ,4 ]
Triggiani, Vincenzo [1 ]
机构
[1] Univ Bari, Sch Med, Sect Internal Med Geriatr Endocrinol & Rare Dis, Policlin,Interdisciplinary Dept Med, Bari, Italy
[2] Rutigliano, Bari, Italy
[3] Univ Bologna, S Orsola Malpighi Hosp, Alma Mater Studiorum, Div Endocrinol,Dept Med & Surg Sci, Bologna, Italy
[4] Univ Bologna, S Orsola Malpighi Hosp, Alma Mater Studiorum, Ctr Appl Biomed Res,Dept Med & Surg Sci, Bologna, Italy
来源
HYPERANDROGENISM IN WOMEN: BEYOND POLYCYSTIC OVARY SYNDROME | 2019年 / 53卷
关键词
CAG REPEAT POLYMORPHISM; SITE-RELATED SPECIFICITIES; POLYCYSTIC-OVARY-SYNDROME; ADIPOSE-TISSUE; PROSTATE-CANCER; DEPRIVATION THERAPY; TESTOSTERONE THERAPY; INSULIN-RESISTANCE; RECEPTOR GENE; 5-ALPHA-REDUCTASE ACTIVITY;
D O I
10.1159/000494900
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Differences between males and females are commonly attributed to sexual hormones. Androgens are responsible for the development of primary and secondary sexual characteristics in males, whereas they influence sexual behaviour, glycaemic control, lipid profile, bone metabolism and erythropoiesis in both sexes. In this chapter, we discuss preclinical and clinical data on sex-specific androgen metabolism and androgen effect on body composition. (c) 2019 S. Karger AG, Basel
引用
收藏
页码:18 / 32
页数:15
相关论文
共 100 条
[61]   The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders [J].
Miller, Walter L. ;
Auchus, Richard J. .
ENDOCRINE REVIEWS, 2011, 32 (01) :81-151
[62]   Divergences in Insulin Resistance Between the Different Phenotypes of the Polycystic Ovary Syndrome [J].
Moghetti, Paolo ;
Tosi, Flavia ;
Bonin, Cecilia ;
Di Sarra, Daniela ;
Fiers, Tom ;
Kaufman, Jean-Marc ;
Giagulli, Vito Angelo ;
Signori, Chiara ;
Zambotti, Francesca ;
Dall'Alda, Marlene ;
Spiazzi, Giovanna ;
Zanolin, Maria Elisabetta ;
Bonora, Enzo .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (04) :E628-E637
[63]   Metabolic syndrome induces inflammation and impairs gonadotropin-releasing hormone neurons in the preoptic area of the hypothalamus in rabbits [J].
Morelli, Annamaria ;
Sarchielli, Erica ;
Comeglio, Paolo ;
Filippi, Sandra ;
Vignozzi, Linda ;
Marini, Mirca ;
Rastrelli, Giulia ;
Maneschi, Elena ;
Cellai, Ilaria ;
Persani, Luca ;
Adorini, Luciano ;
Vannelli, Gabriella B. ;
Maggi, Mario .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2014, 382 (01) :107-119
[64]   The impact of the CAG repeat polymorphism of the androgen receptor gene on muscle and adipose tissues in 20-29-year-old Danish men: Odense Androgen Study [J].
Nielsen, Torben Leo ;
Hagen, Claus ;
Wraae, Kristian ;
Bathum, Lise ;
Larsen, Rasmus ;
Brixen, Kim ;
Andersen, Marianne .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2010, 162 (04) :795-804
[65]  
Nuttall F.Q., 2015, Nutrition Today, V50, P117, DOI [10.1097/NT.0000000000000092, DOI 10.1097/NT.0000000000000092]
[66]   Androgen effects on skeletal muscle: implications for the development and management of frailty [J].
O'Connell, Matthew D. L. ;
Wu, Frederick C. W. .
ASIAN JOURNAL OF ANDROLOGY, 2014, 16 (02) :203-212
[67]   AKR1C3-Mediated Adipose Androgen Generation Drives Lipotoxicity in Women With Polycystic Ovary Syndrome [J].
O'Reilly, Michael W. ;
Kempegowda, Punith ;
Walsh, Mark ;
Taylor, Angela E. ;
Manolopoulos, Konstantinos N. ;
Allwood, J. William ;
Semple, Robert K. ;
Hebenstreit, Daniel ;
Dunn, Warwick B. ;
Tomlinson, Jeremy W. ;
Arlt, Wiebke .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102 (09) :3327-3339
[68]   Lifestyle guidelines for managing adverse effects on bone health and body composition in men treated with androgen deprivation therapy for prostate cancer: an update [J].
Owen, P. J. ;
Daly, R. M. ;
Livingston, P. M. ;
Fraser, S. F. .
PROSTATE CANCER AND PROSTATIC DISEASES, 2017, 20 (02) :137-145
[69]   Defining Hyperandrogenism in Women With Polycystic Ovary Syndrome: A Challenging Perspective [J].
Pasquali, Renato ;
Zanotti, Laura ;
Fanelli, Flaminia ;
Mezzullo, Marco ;
Fazzini, Alessia ;
Labate, Antonio Maria Morselli ;
Repaci, Andrea ;
Ribichini, Danilo ;
Gambineri, Alessandra .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (05) :2013-2022
[70]  
Pasquali R, 2015, WOMENS HEALTH, V11, P501, DOI [10.2217/WHE.15.13, 10.2217/whe.15.13]