Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: cost effectiveness analysis

被引:132
作者
Gillett, M. [1 ]
Dallosso, H. M. [2 ]
Dixon, S. [1 ]
Brennan, A. [1 ]
Carey, M. E. [2 ]
Campbell, M. J. [1 ]
Heller, S. [3 ]
Khunti, K. [4 ]
Skinner, T. C. [5 ]
Davies, M. J. [6 ]
机构
[1] Univ Sheffield, Sch Hlth & Related Res ScHARR, Sheffield, S Yorkshire, England
[2] Univ Hosp Leicester NHS Trust, DESMOND Project Off, Leicester, Leics, England
[3] Univ Sheffield, Sch Med & Biomed Sci, Acad Unit Diabet Endocrinol & Metab, Sheffield, S Yorkshire, England
[4] Univ Leicester, Dept Hlth Sci, Leicester, Leics, England
[5] Combined Univ Ctr Rural Hlth, Geraldton, Australia
[6] Univ Leicester, Leicester Royal Infirm, Dept Cardiovasc Med, Leicester, Leics, England
来源
BMJ-BRITISH MEDICAL JOURNAL | 2010年 / 341卷
关键词
CLUSTER RANDOMIZED-TRIALS; QUALITY-OF-LIFE; UKPDS; MODEL; WEIGHT; IMPACT; STYLE; RISK;
D O I
10.1136/bmj.c4093
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives To assess the long term clinical and cost effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) intervention compared with usual care in people with newly diagnosed type 2 diabetes. Design We undertook a cost-utility analysis that used data from a 12 month, multicentre, cluster randomised controlled trial and, using the Sheffield type 2 diabetes model, modelled long term outcomes in terms of use of therapies, incidence of complications, mortality, and associated effect on costs and health related quality of life. A further cost-utility analysis was also conducted using current "real world" costs of delivering the intervention estimated for a hypothetical primary care trust. Setting Primary care trusts in the United Kingdom. Participants Patients with newly diagnosed type 2 diabetes. Intervention A six hour structured group education programme delivered in the community by two professional healthcare educators. Main outcome measures Incremental costs and quality adjusted life years (QALYs) gained. Results On the basis of the data in the trial, the estimated mean incremental lifetime cost per person receiving the DESMOND intervention is 209 pound (95% confidence interval -704 pound to 1137; pound (sic)251, -(sic)844 to (sic)1363; $326, -$1098 to $1773), the incremental gain in QALYs per person is 0.0392 (-0.0813 to 0.1786), and the mean incremental cost per QALY is 5387 pound. Using "real world" intervention costs, the lifetime incremental cost of the DESMOND intervention is 82 pound (-831 pound to 1010) pound and the mean incremental cost per QALY gained is 2092 pound. A probabilistic sensitivity analysis indicated that the likelihood that the DESMOND programme is cost effective at a threshold of 20 pound 000 per QALY is 66% using trial based intervention costs and 70% using "real world" costs. Results from a one way sensitivity analysis suggest that the DESMOND intervention is cost effective even under more modest assumptions that include the effects of the intervention being lost after one year. Conclusion Our results suggest that the DESMOND intervention is likely to be cost effective compared with usual care, especially with respect to the real world cost of the intervention to primary care trusts, with reductions in weight and smoking being the main benefits delivered.
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