Host-directed therapies offer novel opportunities for the fight against tuberculosis

被引：31
|
作者：
Machelart, Arnaud [1 ]
Song, Ok-Ryul [1 ]
Hoffmann, Eik [1 ]
Brodin, Priscille [1 ]
机构：
[1] Univ Lille, CHU Lille, Inst Pasteur Lille, INSERM,U1019,CNRS,UMR 8204,CIIL, F-59000 Lille, France
来源：
DRUG DISCOVERY TODAY | 2017年 / 22卷 / 08期
基金：
欧洲研究理事会;
关键词：
MYCOBACTERIUM-TUBERCULOSIS; VITAMIN-D; NUCLEAR RECEPTORS; DOUBLE-BLIND; MACROPHAGE; GRANULOMA; AUTOPHAGY; INFECTION; GROWTH; GAMMA;
D O I：
10.1016/j.drudis.2017.05.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Tuberculosis (TB) remains a leading global health problem that is exacerbated by the emergence of multidrug and extensively drug-resistant Mycobacterium tuberculosis strains. Control of the disease requires novel therapeutic strategies. Modulating host homeostasis appears to be a promising approach, and recent studies have identified novel potential host targets and compounds that could be investigated for host-directed therapies (HDTs). Moreover, the recent development of intracellular high-throughput phenotypic assays makes it possible to screen large libraries of compounds to identify more rapidly new effectors for mycobacterial elimination. Technological advances combined with the novel HDT concept opens an interesting and promising research area that could ultimately deliver personalized TB treatment.
引用
收藏
页码：1250 / 1257
页数：8
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