Fuchs Endothelial Corneal Dystrophy

被引：171

作者：

Elhalis, Hussain ^{[1
,3
]}

Azizi, Behrooz ^{[1
,3
]}

Jurkunas, Ula V. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, Schepens Eye Res Inst, Boston, MA 02114 USA

[2] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Boston, MA 02114 USA

[3] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA

来源：

OCULAR SURFACE | 2010年 / 8卷 / 04期

关键词：

antioxidants; apoptosis; collagen VIII; corneal endothelium; Fuchs endothelial corneal dystrophy; genetics; oxidative stress; proteomics; GROWTH-FACTOR-BETA; THIOL-SPECIFIC ANTIOXIDANT; INDUCED PROTEIN TGFBIP; DESCEMETS-MEMBRANE; OXIDATIVE STRESS; INTERSTITIAL KERATITIS; PEROXIREDOXIN SUBTYPES; CLUSTERIN EXPRESSION; ALZHEIMERS-DISEASE; EPITHELIAL-CELLS;

D O I：

10.1016/S1542-0124(12)70232-X

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Fuchs endothelial corneal dystrophy (FECD) Is characterized by progressive loss of corneal endothelial cells, thickening of Descement's membrane and deposition of extracellular matrix in the form of guttae. When the number of endothelial cells becomes critically low, the cornea swells and causes loss of vision. The clinical course of FECD usually spans 10-20 years. Corneal transplantation is currently the only modality used to restore vision. Over the last several decades genetic studies have detected several genes, as well as areas of chromosomal loci associated with the disease. Proteomic studies have given rise to several hypotheses regarding the pathogenesis of FECD. This review expands upon the recent findings from proteomic and genetic studies and builds upon recent advances in understanding the causes of this common corneal disorder.

引用

页码：173 / 184

页数：12

共 111 条

[31] Fuchs corneal dystrophy:: Aberrant collagen distribution in an L450W mutant of the COL8A2 gene [J].

Gottsch, JD ;

Zhang, C ;

Sundin, OH ;

Bell, WR ;

Stark, WJ ;

Green, WR .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (12) :4504-4511

[32] Serial analysis of gene expression in the corneal endothelium of Fuchs' dystrophy [J].

Gottsch, JD ;

Bowers, AL ;

Margulies, EH ;

Seitzman, GD ;

Kim, SW ;

Saha, S ;

Jun, AS ;

Stark, WJ ;

Liu, SH .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (02) :594-599

[33] Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen [J].

Hashimoto, K ;

Noshiro, M ;

Ohno, S ;

Kawamoto, T ;

Satakeda, H ;

Akagawa, Y ;

Nakashima, K ;

Okimura, A ;

Ishida, H ;

Okamoto, T ;

Pan, H ;

Shen, M ;

Yan, WQ ;

Kato, Y .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1997, 1355 (03) :303-314

[34] Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye [J].

Hopfer, U ;

Fukai, N ;

Hopfer, H ;

Wolf, G ;

Joyce, N ;

Li, E ;

Olsen, BR .

FASEB JOURNAL, 2005, 19 (10) :1232-1244

[35]

IWAMOTO T, 1971, INVEST OPHTH VISUAL, V10, P9

[36]

*J HOPK U MCKUS NA, 2009, ONL MEND INH MAN OMI

[37]

JAKUS MARIE A., 1956, JOUR BIOPHYS AND BIOCHEM CYTOL, V2, P243, DOI 10.1083/jcb.2.4.243

[38]

JOHNS DR, 1995, NEW ENGL J MED, V333, P638, DOI 10.1056/NEJM199509073331007

[39] THE ULTRASTRUCTURE OF DESCEMETS MEMBRANE .1. CHANGES WITH AGE IN NORMAL CORNEAS [J].

JOHNSON, DH ;

BOURNE, WM ;

CAMPBELL, J .

ARCHIVES OF OPHTHALMOLOGY, 1982, 100 (12) :1942-1947

[40] Potential complications of ocular surgery in patients with coexistent keratoconus and Fuchs' endothelial dystrophy [J].

Jurkunas, Ula ;

Azar, Dimitri T. .

OPHTHALMOLOGY, 2006, 113 (12) :2187-2197

← 1 2 3 4 5 6 7 8 9 10 →