Association of a TGF-β1 gene -509 C/T polymorphism with breast cancer risk: a meta-analysis

被引：14

作者：

Woo, Sang Uk ^{[2
]}

Park, Kyong Hwa ^{[1
]}

Woo, Ok Hee ^{[3
]}

Yang, Dae Sik ^{[4
]}

Kim, Ae-Ree ^{[5
]}

Lee, Eun Sook ^{[2
]}

Lee, Jae-Bok ^{[2
]}

Kim, Yeul Hong ^{[1
]}

Kim, Jun Suk ^{[1
]}

Seo, Jae Hong ^{[1
]}

机构：

[1] Korea Univ, Guro Hosp, Div Med Oncol, Dept Internal Med,Guro Ku, Seoul, South Korea

[2] Korea Univ, Guro Hosp, Dept Surg, Guro Ku, Seoul, South Korea

[3] Korea Univ, Guro Hosp, Dept Diagnost Radiol, Guro Ku, Seoul, South Korea

[4] Korea Univ, Guro Hosp, Dept Radiat Oncol, Guro Ku, Seoul, South Korea

[5] Korea Univ, Guro Hosp, Dept Pathol, Guro Ku, Seoul, South Korea

来源：

BREAST CANCER RESEARCH AND TREATMENT | 2010年 / 124卷 / 02期

关键词：

TGF-beta; 1; -509 C/T polymorphism; Breast cancer risk; Meta-analysis; TGF-BETA SUPERFAMILY; SIGNAL-TRANSDUCTION; HUMAN-DISEASE; TRANSFORMING-GROWTH-FACTOR-BETA-1; MECHANISMS; RAS;

D O I：

10.1007/s10549-010-0871-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Transforming growth factor-beta 1 (TGF-beta 1) is negative regulator of cell proliferation and the cell cycle, and plasma levels of TGF-beta 1 are twice as high in TGF-beta 1 -509 T homozygotes as in -509 C homozygotes. Published studies on the association between the TGF-beta 1 gene -509 C/T polymorphism and breast cancer risk are inconclusive, and a meta-analysis is required to verify the association. We performed a meta-analysis of four studies, including a total of 5,986 cases and 6,829 controls. Our pooled results indicate that the TGF-beta 1 gene -509 C/T polymorphism is not associated with breast cancer risk in a TT versus CC codominant (OR = 1.08; 95% CI = 0.87-1.34; P = 0.494), in a CT versus CC codominant (OR = 1.02; 95% CI = 0.94-1.10; P = 0.686), recessive (OR = 0.92; 95% CI = 0.83-1.03; P = 0.157), and dominant (OR = 1.03; 95% CI = 0.96-1.11; P = 0.439) models. Conclusively, this meta-analysis suggests that the TGF-beta 1 gene -509 T allele polymorphism does not decrease breast cancer risk.

引用

页码：481 / 485

页数：5

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