MicroRNAs: Small RNAs With Big Effects

被引：142
作者：
Anglicheau, Dany [1 ,2 ,3 ,4 ]
Muthukumar, Thangamani [1 ,5 ]
Suthanthiran, Manikkam [1 ,5 ]
机构：
[1] Weill Cornell Med Ctr, Div Nephrol, Dept Med, New York, NY USA
[2] Hop Necker Enfants Malad, APHP, Dept Kidney Transplantat, Paris, France
[3] Univ Paris 05, Paris, France
[4] INSERM, UMR S775, Paris, France
[5] Weill Cornell Med Ctr, Div Nephrol, Dept Transplantat Med, New York, NY USA
来源：
TRANSPLANTATION | 2010年 / 90卷 / 02期
关键词：
Transplantation; Biomarker; MicroRNA; Immune Monitoring; Diagnosis; SMALL INTERFERING RNA; IMMUNE-SYSTEM; EXPRESSION PROFILES; EPITHELIAL-CELLS; MIR-200; FAMILY; C-ELEGANS; DICER; GENE; DIFFERENTIATION; TRANSPLANTATION;
D O I：
10.1097/TP.0b013e3181e913c2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
MicroRNAs (miRNAs) are evolutionarily conserved, small (similar to 20-25 nucleotides), single-stranded molecules that suppress the expression of protein-coding genes by translational repression, messenger RNA degradation, or both. More than 700 miRNAs have been identified in the human genome. Amazingly, a single miRNA can regulate the expression of hundreds of mRNAs or proteins within a cell. The small RNAs are fast emerging as master regulators of innate and adaptive immunity and likely to play a pivotal role in transplantation. The clinical application of RNA sequencing ("next-generation sequencing") should facilitate transcriptome profiling at an unprecedented resolution. We provide an overview of miRNA biology and their hypothesized roles in transplantation.
引用
收藏
页码：105 / 112
页数：8
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