MicroRNAs: Small RNAs With Big Effects

被引：142

作者：

Anglicheau, Dany ^{[1
,2
,3
,4
]}

Muthukumar, Thangamani ^{[1
,5
]}

Suthanthiran, Manikkam ^{[1
,5
]}

机构：

[1] Weill Cornell Med Ctr, Div Nephrol, Dept Med, New York, NY USA

[2] Hop Necker Enfants Malad, APHP, Dept Kidney Transplantat, Paris, France

[3] Univ Paris 05, Paris, France

[4] INSERM, UMR S775, Paris, France

[5] Weill Cornell Med Ctr, Div Nephrol, Dept Transplantat Med, New York, NY USA

来源：

TRANSPLANTATION | 2010年 / 90卷 / 02期

关键词：

Transplantation; Biomarker; MicroRNA; Immune Monitoring; Diagnosis; SMALL INTERFERING RNA; IMMUNE-SYSTEM; EXPRESSION PROFILES; EPITHELIAL-CELLS; MIR-200; FAMILY; C-ELEGANS; DICER; GENE; DIFFERENTIATION; TRANSPLANTATION;

D O I：

10.1097/TP.0b013e3181e913c2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MicroRNAs (miRNAs) are evolutionarily conserved, small (similar to 20-25 nucleotides), single-stranded molecules that suppress the expression of protein-coding genes by translational repression, messenger RNA degradation, or both. More than 700 miRNAs have been identified in the human genome. Amazingly, a single miRNA can regulate the expression of hundreds of mRNAs or proteins within a cell. The small RNAs are fast emerging as master regulators of innate and adaptive immunity and likely to play a pivotal role in transplantation. The clinical application of RNA sequencing ("next-generation sequencing") should facilitate transcriptome profiling at an unprecedented resolution. We provide an overview of miRNA biology and their hypothesized roles in transplantation.

引用

页码：105 / 112

页数：8

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