Quantifying Protein Function Specificity in the Gene Ontology

被引：4

作者：

Louie, Brenton ^{[1
,2
]}

Bergen, Silas ^{[1
,3
]}

Higdon, Roger ^{[1
,2
]}

Kolker, Eugene ^{[1
,2
,4
]}

机构：

[1] Seattle Childrens Res Inst, Bioinformat & High Throughput Anal Lab, Seattle, WA USA

[2] Seattle Childrens Hosp, Seattle, WA USA

[3] Univ Washington, Sch Publ Hlth, Dept Biostat, Seattle, WA 98195 USA

[4] Univ Washington, Sch Med, Dept Med Educ & Biomed Informat, Biomed & Hlth Informat Div, Seattle, WA 98195 USA

来源：

STANDARDS IN GENOMIC SCIENCES | 2010年 / 2卷 / 02期

关键词：

protein annotation; protein function; function specificity; STRAIN RD KW20; HAEMOPHILUS-INFLUENZAE; SEMANTIC SIMILARITY; HYPOTHETICAL GENES; MODEL; EXPRESSION; SEQUENCE; BIOLOGY;

D O I：

10.4056/sigs.561626

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Quantitative or numerical metrics of protein function specificity made possible by the Gene Ontology are useful in that they enable development of distance or similarity measures between protein functions. Here we describe how to calculate four measures of function specificity for GO terms: 1) number of ancestor terms; 2) number of offspring terms; 3) proportion of terms; and 4) Information Content (IC). We discuss the relationship between the metrics and the strengths and weaknesses of each.

引用

页码：238 / 244

页数：7

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