Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium

被引：23

作者：

Chibnik, Lori B. ^{[1
,2
]}

Wolters, Frank J. ^{[1
,3
]}

Backman, Kristoffer ^{[5
]}

Beiser, Alexa ^{[6
,7
,8
]}

Berr, Claudine ^{[9
]}

Bis, Joshua C. ^{[10
]}

Boerwinkle, Eric ^{[12
]}

Bos, Daniel ^{[1
,3
,4
]}

Brayne, Carol ^{[13
]}

Dartigues, Jean-Francois ^{[14
]}

Darweesh, Sirwan K. L. ^{[1
,3
]}

Debette, Stephanie ^{[14
,15
]}

Davis-Plourde, Kendra L. ^{[7
,8
]}

Dufouil, Carole ^{[14
]}

Fornage, Myriam ^{[16
]}

Grasset, Leslie ^{[14
]}

Gudnason, Vilmundur ^{[17
,18
]}

Hadjichrysanthou, Christoforos ^{[19
]}

Helmer, Catherine ^{[14
]}

Ikram, M. Arfan ^{[3
]}

Ikram, M. Kamran ^{[3
]}

Kern, Silke ^{[5
]}

Kuller, Lewis H. ^{[20
]}

Launer, Lenore ^{[21
]}

Lopez, Oscar L. ^{[24
,25
]}

Matthews, Fiona ^{[22
]}

Meirelles, Osorio ^{[21
]}

Mosley, Thomas ^{[23
]}

Ower, Alison ^{[19
]}

Psaty, Bruce M. ^{[10
,11
]}

Satizabal, Claudia L. ^{[6
]}

Seshadri, Sudha ^{[6
]}

Skoog, Ingmar ^{[5
]}

Stephan, Blossom C. M. ^{[22
]}

Tzourio, Christophe ^{[14
]}

Waziry, Reem ^{[1
]}

Wong, Mei Mei ^{[19
]}

Zettergren, Anna ^{[5
]}

Hofman, Albert ^{[1
,3
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, 677 Huntington Ave,Kresge 905, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA

[3] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[4] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

[5] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden

[6] Boston Univ, Sch Med, Boston, MA 02118 USA

[7] Framingham Heart Dis Epidemiol Study, Framingham, MA USA

[8] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA

[9] Univ Montpellier, Neuropsychiat Epidemiol & Clin Res, INSERM, Montpellier, France

[10] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA

[11] Kaiser Permanente Washington Hlth Res Inst, Seattle, WA USA

[12] Univ Texas Sch Publ Hlth, Houston, TX USA

[13] Univ Cambridge, Cambridge, England

[14] Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, F-33000 Bordeaux, France

[15] Bordeaux Univ Hosp, Dept Neurol, Memory Clin, Bordeaux, France

[16] Univ Texas Hlth Sci Ctr Houston, Houston McGovern Med Sch, Houston, TX 77030 USA

[17] Iceland Heart Assoc, Kpavogur, Iceland

[18] Univ Iceland, Fac Med, Reykjavik, Iceland

[19] Imperial Coll London, Sch Publ Hlth, Dept Infect Dis Epidemiol, London, England

[20] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA

[21] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA

[22] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England

[23] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA

[24] Univ Pittsburgh, Dept Neurol, Pittsburgh, PA 15260 USA

[25] Univ Pittsburgh, Dept Psychiat, Pittsburgh, PA USA

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 2017年 / 32卷 / 10期

基金：

欧盟地平线“2020”; 瑞典研究理事会; 英国医学研究理事会;

关键词：

Alzheimer disease; Cohort analysis; Epidemiology; Consortium; COGNITIVE FUNCTION; PREVALENCE; DISEASE; HEART;

D O I：

10.1007/s10654-017-0320-5

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Several studies have reported a decline in incidence of dementia which may have large implications for the projected burden of disease, and provide important guidance to preventive efforts. However, reports are conflicting or inconclusive with regard to the impact of gender and education with underlying causes of a presumed declining trend remaining largely unidentified. The Alzheimer Cohorts Consortium aggregates data from nine international population-based cohorts to determine changes in the incidence of dementia since 1990. We will employ Poisson regression models to calculate incidence rates in each cohort and Cox proportional hazard regression to compare 5-year cumulative hazards across study-specific epochs. Finally, we will meta-analyse changes per decade across cohorts, and repeat all analysis stratified by sex, education and APOE genotype. In all cohorts combined, there are data on almost 69,000 people at risk of dementia with the range of follow-up years between 2 and 27. The average age at baseline is similar across cohorts ranging between 72 and 77. Uniting a wide range of disease-specific and methodological expertise in research teams, the first analyses within the Alzheimer Cohorts Consortium are underway to tackle outstanding challenges in the assessment of time-trends in dementia occurrence.

引用

页码：931 / 938

页数：8

共 26 条

[1] Vascular factors and risk of dementia: Design of the three-city study and baseline characteristics of the study population [J].

Alperovitch, A .

NEUROEPIDEMIOLOGY, 2003, 22 (06) :316-325

[2]

BENGTSSON C, 1973, ACTA MED SCAND, P311

[3] Selected Findings from the Religious Orders Study and Rush Memory and Aging Project [J].

Bennett, David A. ;

Wilson, Robert S. ;

Arvanitakis, Zoe ;

Boyle, Patricia A. ;

de Toledo-Morrell, Leyla ;

Schneider, Julie A. .

JOURNAL OF ALZHEIMERS DISEASE, 2013, 33 :S397-S403

[4]

DARTIGUES JF, 1991, REV NEUROL-FRANCE, V147, P225

[5]

DAWBER TR, 1951, AM J PUBLIC HEALTH, V41, P279

[6] FRAMINGHAM OFFSPRING STUDY - DESIGN AND PRELIMINARY DATA [J].

FEINLEIB, M ;

KANNEL, WB ;

GARRISON, RJ ;

MCNAMARA, PM ;

CASTELLI, WP .

PREVENTIVE MEDICINE, 1975, 4 (04) :518-525

[7]

Fried Linda P., 1991, Annals of Epidemiology, V1, P263

[8] Trends in dementia incidence: Evolution over a 10-year period in France [J].

Grasset, Leslie ;

Brayne, Carol ;

Joly, Pierre ;

Jacqmin-Gadda, Helene ;

Peres, Karine ;

Foubert-Samier, Alexandra ;

Dartigues, Jean-Francois ;

Helmer, Catherine .

ALZHEIMERS & DEMENTIA, 2016, 12 (03) :272-280

[9] Age, Gene/Environment Susceptibility-Reykjavik Study: Multidisciplinary applied phenomics [J].

Harris, Tamara B. ;

Launer, Lenore J. ;

Eiriksdottir, Gudny ;

Kjartansson, Olafur ;

Jonsson, Palmi V. ;

Sigurdsson, Gunnar ;

Thorgeirsson, Gudmundur ;

Aspelund, Thor ;

Garcia, Melissa E. ;

Cotch, Mary Frances ;

Hoffman, Howard J. ;

Gudnason, Vilmundur .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 165 (09) :1076-1087

[10] The Rotterdam Study: 2016 objectives and design update [J].

Hofman, Albert ;

Brusselle, Guy G. O. ;

Murad, Sarwa Darwish ;

van Duijn, Cornelia M. ;

Franco, Oscar H. ;

Goedegebure, Andre ;

Ikram, M. Arfan ;

Klaver, Caroline C. W. ;

Nijsten, Tamar E. C. ;

Peeters, Robin P. ;

Stricker, Bruno H. Ch. ;

Tiemeier, Henning W. ;

Uitterlinden, Andre G. ;

Vernooij, Meike W. .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2015, 30 (08) :661-708

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