The interaction of fibroblast growth factor/fibroblast growth factor receptor and FGF inhibitors

被引：0

作者：

Fan, HK ^{[1
]}

Zhou, H ^{[1
]}

Li, W ^{[1
]}

机构：

[1] Jilin Univ, Coll Life Sci, Changchun 130023, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2001年 / 28卷 / 03期

关键词：

fibroblast growth factor; receptor; heparin; inhibitor;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fibroblast growth factor (FGF) family contains at least nineteen members that play important roles in embryogenesis, vascularization, neuron system growth and in development and pathological states. In order to study the mechanism of interaction of FGF/FGFR, plenty of research work was focused on the study of structure and function of FGF and FGFR. Heparin binding domain of aFGF and bFGF, and receptor binding domain of bFGF have been identified. Heparin binding domain and ligands binding domain of FGFR also were localized. Based on the research, two models of interaction of FGF/FGFR were presented and many nucleotide, saccharides and peptide inhibitors were developed. The inhibitors may play an important role in the designing of anti-cancer drug.

引用

页码：338 / 341

页数：4

共 19 条

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