MicroRNA-873 (MiRNA-873) Inhibits Glioblastoma Tumorigenesis and Metastasis by Suppressing the Expression of IGF2BP1

被引：101

作者：

Wang, Ren-jie ^{[1
]}

Li, Jian-wei ^{[2
]}

Bao, Bu-he ^{[1
]}

Wu, Huan-cheng ^{[2
]}

Du, Zhen-hua ^{[1
]}

Su, Jing-liang ^{[2
]}

Zhang, Ming-hua ^{[1
]}

Liang, Hai-qian ^{[2
]}

机构：

[1] Logist Coll Armed Police Forces, Pingjin Hosp, Dept Clin Lab, Tianjin 300162, Peoples R China

[2] Logist Coll Armed Police Forces, Pingjin Hosp, Dept Neurosurg, Tianjin 300162, Peoples R China

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2015年 / 290卷 / 14期

关键词：

C-MYC; GLIOMA; GROWTH; RNA; BRAIN; PROLIFERATION; PROTEINS; CANCER; TUMORS; CELLS;

D O I：

10.1074/jbc.M114.624700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioblastoma multiforme (GBM) is known as a highly malignant brain tumor with a poor prognosis, despite intensive research and clinical efforts. In this study, we observed that microRNA-873 (miR-873) was expressed at low levels in GBM and that the overexpression of miR-873 dramatically reduced the cell proliferation, migration, and invasion of GBM cells. Our further investigations of the inhibition mechanism indicated that miR-873 negatively affected the carcinogenesis and metastasis of GBM by down-regulating the expression of IGF2BP1, which stabilizes the mRNA transcripts of its target genes. These results demonstrate that miR-873 may constitute a potential target for GBM therapy.

引用

页码：8938 / 8948

页数：11

共 38 条

[11] Oncogenic effects of miR-10b in glioblastoma stem cells [J].

Guessous, Fadila ;

Alvarado-Velez, Melissa ;

Marcinkiewicz, Lukasz ;

Zhang, Ying ;

Kim, Jungeun ;

Heister, Simon ;

Kefas, Benjamin ;

Godlewski, Jakub ;

Schiff, David ;

Purow, Benjamin ;

Abounader, Roger .

JOURNAL OF NEURO-ONCOLOGY, 2013, 112 (02) :153-163

[12] microRNA-34a is tumor suppressive in brain tumors and glioma stem cells [J].

Guessous, Fadila ;

Zhang, Ying ;

Kofman, Alexander ;

Catania, Alessia ;

Li, Yunqing ;

Schiff, David ;

Purow, Benjamin ;

Abounader, Roger .

CELL CYCLE, 2010, 9 (06) :1031-1036

[13] Insulin-Like Growth Factor 2 mRNA-Binding Protein 1 (IGF2BP1) Is an Important Protumorigenic Factor in Hepatocellular Carcinoma [J].

Gutschner, Tony ;

Haemmerle, Monika ;

Pazaitis, Nikolaos ;

Bley, Nadine ;

Fiskin, Evgenij ;

Uckelmann, Hannah ;

Heim, Andreas ;

Gross, Matthias ;

Hofmann, Nina ;

Geffers, Robert ;

Skawran, Britta ;

Longerich, Thomas ;

Breuhahn, Kai ;

Schirmacher, Peter ;

Muehleck, Britta ;

Huettelmaier, Stefan ;

Diederichs, Sven .

HEPATOLOGY, 2014, 59 (05) :1900-1911

[14] MicroRNA-195 Inhibits the Proliferation of Human Glioma Cells by Directly Targeting Cyclin D1 and Cyclin E1 [J].

Wang Hui ;

Lu Yuntao ;

Luo Lun ;

Li WenSheng ;

Liang ChaoFeng ;

He HaiYong ;

Ba Yueyang .

PLOS ONE, 2013, 8 (01)

[15] Tumorigenesis of chemotherapeutic drug-resistant cancer stem-like cells in brain glioma [J].

Kang, Mi-Kyung ;

Kang, Soo-Kyung .

STEM CELLS AND DEVELOPMENT, 2007, 16 (05) :837-847

[16]

Kanu OO, 2009, CLIN MED INSIGHTS-ON, V3, P39

[17] Expression of the RNA-binding protein IMP1 correlates with poor prognosis in ovarian carcinoma [J].

Koebel, M. ;

Weidensdorfer, D. ;

Reinke, C. ;

Lederer, M. ;

Schmitt, W. D. ;

Zeng, K. ;

Thomssen, C. ;

Hauptmann, S. ;

Huettelmaier, S. .

ONCOGENE, 2007, 26 (54) :7584-7589

[18] Annual Report to the Nation on the Status of Cancer, 1975-2007, Featuring Tumors of the Brain and Other Nervous System [J].

Kohler, Betsy A. ;

Ward, Elizabeth ;

McCarthy, Bridget J. ;

Schymura, Maria J. ;

Ries, Lynn A. G. ;

Eheman, Christie ;

Jemal, Ahmedin ;

Anderson, Robert N. ;

Ajani, Umed A. ;

Edwards, Brenda K. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (09) :714-736

[19] The 2007 WHO classification of tumours of the central nervous system (vol 114, pg 97, 2007) [J].

Louis, David N. ;

Ohgaki, Hiroko ;

Wiestler, Otmar D. ;

Cavenee, Webster K. ;

Burger, Peter C. ;

Jouvet, Anne ;

Scheithauer, Bernd W. ;

Kleihues, Paul .

ACTA NEUROPATHOLOGICA, 2007, 114 (05) :547-547

[20] Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas [J].

Ohgaki, H ;

Kleihues, P .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2005, 64 (06) :479-489

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