MicroRNA-873 (MiRNA-873) Inhibits Glioblastoma Tumorigenesis and Metastasis by Suppressing the Expression of IGF2BP1

被引：101

作者：

Wang, Ren-jie ^{[1
]}

Li, Jian-wei ^{[2
]}

Bao, Bu-he ^{[1
]}

Wu, Huan-cheng ^{[2
]}

Du, Zhen-hua ^{[1
]}

Su, Jing-liang ^{[2
]}

Zhang, Ming-hua ^{[1
]}

Liang, Hai-qian ^{[2
]}

机构：

[1] Logist Coll Armed Police Forces, Pingjin Hosp, Dept Clin Lab, Tianjin 300162, Peoples R China

[2] Logist Coll Armed Police Forces, Pingjin Hosp, Dept Neurosurg, Tianjin 300162, Peoples R China

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2015年 / 290卷 / 14期

关键词：

C-MYC; GLIOMA; GROWTH; RNA; BRAIN; PROLIFERATION; PROTEINS; CANCER; TUMORS; CELLS;

D O I：

10.1074/jbc.M114.624700

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glioblastoma multiforme (GBM) is known as a highly malignant brain tumor with a poor prognosis, despite intensive research and clinical efforts. In this study, we observed that microRNA-873 (miR-873) was expressed at low levels in GBM and that the overexpression of miR-873 dramatically reduced the cell proliferation, migration, and invasion of GBM cells. Our further investigations of the inhibition mechanism indicated that miR-873 negatively affected the carcinogenesis and metastasis of GBM by down-regulating the expression of IGF2BP1, which stabilizes the mRNA transcripts of its target genes. These results demonstrate that miR-873 may constitute a potential target for GBM therapy.

引用

页码：8938 / 8948

页数：11

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