Norovirus recombination

被引:271
作者
Bull, Rowena A. [1 ]
Tanaka, Mark M. [1 ]
White, Peter A. [1 ]
机构
[1] Univ New S Wales, Fac Sci, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
关键词
D O I
10.1099/vir.0.83321-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
RNA recombination is a significant driving force in viral evolution. Increased awareness of recombination within the genus Norovirus of the family Calicivirus has led to a rise in the identification of norovirus (NoV) recombinants and they are now reported at high frequency. Currently, there is no classification system for recombinant NoVs and a widely accepted recombinant genotyping system is still needed. Consequently, there is duplication in reporting of novel recombinants. This has led to difficulties in defining the number and types of recombinants in circulation. In this study, 120 NoV nucleotide sequences were compiled from the current GenBank database and published literature. NoV recombinants and their recombination breakpoints were identified using three methods: phylogenetic analysis, SimPlot analysis and 2 the maximum X method. A total of 20 NoV recombinant types were identified in circulation worldwide. The recombination point is the ORF1/2 overlap in all isolates except one, which demonstrated a double recombination event within the polymerase region.
引用
收藏
页码:3347 / 3359
页数:13
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