Synthesis of nitric oxide-releasing gold nanoparticles

被引：110

作者：

Rothrock, AR ^{[1
]}

Donkers, RL ^{[1
]}

Schoenfisch, MH ^{[1
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 26期

关键词：

D O I：

10.1021/ja052027u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the synthesis of nitric oxide-releasing gold nanoparticles formed by place-exchange reaction of hexanethiol monolayer-protected clusters with diamine nitric oxide donor precursor molecules, which are subsequently converted to N-diazeniumdiolate NO donors. The nitric oxide release from the N-diazeniumdiolate-modified gold nanoparticles is tunable by varying the number and/or the chemical structure of the exchanged amine ligands. The size and stability of NO-releasing nanoparticles may prove useful for a range of biomedical and pharmaceutical applications. Copyright © 2005 American Chemical Society.

引用

页码：9362 / 9363

页数：2

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