Determinants of tissue delivery for Xe-129 magnetic resonance in humans

被引：54
作者：
Peled, S
Jolesz, FA
Tseng, CH
Nascimben, L
Albert, MS
Walsworth, RL
机构：
[1] MIT,DIV HLTH SCI & TECHNOL,BOSTON,MA
[2] HARVARD SMITHSONIAN CTR ASTROPHYS,BOSTON,MA
[3] HARVARD UNIV,SCH MED,DEPT RADIOL,BOSTON,MA 02115
[4] HARVARD UNIV,SCH MED,DEPT INTERNAL MED,BOSTON,MA 02115
来源：
MAGNETIC RESONANCE IN MEDICINE | 1996年 / 36卷 / 03期
关键词：
xenon; MRI; NMR;
D O I：
10.1002/mrm.1910360303
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Magnetic resonance imaging using laser-polarized Xe-129 is a new technique first demonstrated by Albert et al, (Nature 370, 1994) who obtained a Xe-129 image of an excised mouse lung, This paper describes the factors influencing the accumulation of inhaled, polarized Xe-129 in human tissue, The resulting model predicts the Xe-129 magnetization in different tissues as a function of the time from the start of inhalation, the tissue perfusion rate and partition coefficient for xenon, and the relevant T-1 decay times, The relaxation times of Xe-129 in biological tissues are not yet known precisely, Substitution of estimated values for these parameters results in an expected signal-to-noise ratio (SNR) from polarized Xe-129 MR in the brain of approximately 2% of the equivalent SNR from proton MR.
引用
收藏
页码：340 / 344
页数：5
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