Cell-Based Drug Delivery Devices Using Phagocytosis-Resistant Backpacks

被引：157

作者：

Doshi, Nishit ^{[2
]}

Swiston, Albert J. ^{[1
]}

Gilbert, Jonathan B. ^{[3
]}

Alcaraz, Maria L. ^{[3
]}

Cohen, Robert E. ^{[3
]}

Rubner, Michael F. ^{[1
]}

Mitragotri, Samir ^{[2
]}

机构：

[1] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[2] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA

[3] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 12期

基金：

美国国家科学基金会;

关键词：

ANTIRETROVIRAL DRUG; HYALURONIC-ACID; SURFACE; INFLAMMATION; MECHANISMS; DISEASE; FILMS; MODEL; SIZE;

D O I：

10.1002/adma.201004074

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macrophages are recruited at the diseased site in several pathological conditions. Here, we describe a novel method of utilizing their unique properties for targeted drug delivery. Cellular backpacks are designed that ride on macrophage surfaces without affecting cell functions or getting internalized. These backpacks can be used as multimodal therapeutic and diagnostic agents. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：H105 / H109

页数：5

共 33 条

[1] Mechanisms of phagocytosis in macrophages [J].

Aderem, A ;

Underhill, DM .

ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 :593-623

[2] Layer-by-layer assembly as a versatile bottom-up nanofabrication technique for exploratory research and realistic application [J].

Ariga, Katsuhiko ;

Hill, Jonathan P. ;

Ji, Qingmin .

PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2007, 9 (19) :2319-2340

[3]

Beningo KA, 2002, J CELL SCI, V115, P849

[4]

Burke B., 2002, MACROPHAGE

[5]

Caruso F, 2001, ADV MATER, V13, P11, DOI 10.1002/1521-4095(200101)13:1<11::AID-ADMA11>3.0.CO

[6]

2-N

[7] Role of target geometry in phagocytosis [J].

Champion, JA ;

Mitragotri, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :4930-4934

[8] Role of particle size in phagocytosis of polymeric microspheres [J].

Champion, Julie A. ;

Walker, Amanda ;

Mitragotri, Samir .

PHARMACEUTICAL RESEARCH, 2008, 25 (08) :1815-1821

[9] Shape Induced Inhibition of Phagocytosis of Polymer Particles [J].

Champion, Julie A. ;

Mitragotri, Samir .

PHARMACEUTICAL RESEARCH, 2009, 26 (01) :244-249

[10] A cellular Trojan horse for delivery of therapeutic nanoparticles into tumors [J].

Choi, Mi-Ran ;

Stanton-Maxey, Katie J. ;

Stanley, Jennifer K. ;

Levin, Carly S. ;

Bardhan, Rizia ;

Akin, Demir ;

Badve, Sunil ;

Sturgis, Jennifer. ;

Robinson, J. Paul ;

Bashir, Rashid ;

Halas, Naomi J. ;

Clare, Susan E. .

NANO LETTERS, 2007, 7 (12) :3759-3765

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