The Mechanisms of Ferroptosis and the Applications in Tumor Treatment: Enemies or Friends?

被引：8

作者：

Tan, Shuzheng ^{[1
,2
]}

Kong, Ying ^{[3
]}

Xian, Yongtong ^{[4
]}

Gao, Pengbo ^{[4
]}

Xu, Yue ^{[4
]}

Wei, Chuzhong ^{[4
]}

Lin, Peixu ^{[4
]}

Ye, Weilong ^{[4
]}

Li, Zesong ^{[5
]}

Zhu, Xiao ^{[1
]}

机构：

[1] Hangzhou Med Coll, Sch Lab Med & Biol Engn, Hangzhou, Peoples R China

[2] Guangzhou Med Univ, Dept Dermatol, Affiliated Hosp 1, Guangzhou, Peoples R China

[3] Jianghan Univ, Dept Clin Lab, Hubei 3 Peoples Hosp, Wuhan, Peoples R China

[4] Guangdong Med Univ, Computat Oncol Lab, Zhanjiang, Peoples R China

[5] Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Schenzhen Inst Translat Med,Shenzhen Key Lab Genit, Shenzhen, Peoples R China

来源：

FRONTIERS IN MOLECULAR BIOSCIENCES | 2022年 / 9卷

基金：

中国国家自然科学基金;

关键词：

ferroptosis; immunotherapy; iron overload; lipid peroxidation; mitochondria; HEME OXYGENASE-1 SYSTEM; CELL-DEATH; PROMOTES FERROPTOSIS; CANCER; METABOLISM; PATHWAY; IRON; P53; ACTIVATION; EXPRESSION;

D O I：

10.3389/fmolb.2022.938677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ferroptosis, as a newly discovered non-apoptotic cell death mode, is beginning to be explored in different cancer. The particularity of ferroptosis lies in the accumulation of iron dependence and lipid peroxides, and it is different from the classical cell death modes such as apoptosis and necrosis in terms of action mode, biochemical characteristics, and genetics. The mechanism of ferroptosis can be divided into many different pathways, so it is particularly important to identify the key sites of ferroptosis in the disease. Herein, based on ferroptosis, we analyze the main pathways in detail. More importantly, ferroptosis is linked to the development of different systems of the tumor, providing personalized plans for the examination, treatment, and prognosis of cancer patients. Although some mechanisms and side effects of ferroptosis still need to be studied, it is still a promising method for cancer treatment.

引用

页数：13

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