Synergistic properties of the terpenoids aromadendrene and 1,8-cineole from the essential oil of Eucalyptus globulus against antibiotic-susceptible and antibiotic-resistant pathogens

被引：282

作者：

Mulyaningsih, S. ^{[1
]}

Sporer, Frank ^{[1
]}

Zimmermann, Stefan ^{[2
]}

Reichling, Jurgen ^{[1
]}

Wink, Michael ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany

[2] Heidelberg Univ, Dept Infect Dis Med Microbiol & Hyg, D-69120 Heidelberg, Germany

来源：

PHYTOMEDICINE | 2010年 / 17卷 / 13期

关键词：

Eucalyptus globulus; Essential oil; Aromadendrene; 1; 8; Cineole; Multidrug resistant bacteria; Synergism; CHEMICAL-COMPOSITION; ANTIMICROBIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; MEDICINAL-PLANTS; FRUITS;

D O I：

10.1016/j.phymed.2010.06.018

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The aim of the present study was to investigate the chemical composition of the essential oil of the fruits of Eucalyptus globulus and to examine the potential application of the fruit oil against multidrug-resistant bacteria GLC/MS analysis in the fruit oil showed that aromadendrene was the main compound followed by 1 8-cineole and globulol The three most abundant components of the fruit oil were also tested individually against microorganisms In addition the synergistic effects of combinations of the major constituents (aromadendrene and 1 8-cineole) of the fruit oil were also investigated All Gram-positive bacteria were susceptible to the fruit oil with different degrees of susceptibility as determined by microdilution method The oil exerted a marked inhibition against multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (vRE) Ente rococcus faecalis The results indicated that aromadendrene might be responsible for the antimicrobial properties whereas 1 8-cineole and globulol exhibited low activities The checkerboard assay demonstrated that combinations of 1 8-cineole and aromadendrene reduce the MIC in most cases in an additive way whereas the time-kill assay indicates a synergistic effect (C) 2010 Elsevier GmbH All rights reserved

引用

页码：1061 / 1066

页数：6

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