Pituitary adenylate cyclase-activating peptide is upregulated in sensory neurons by inflammation

被引：66

作者：

Zhang, YZ ^{[1
]}

Danielsen, N ^{[1
]}

Sundler, F ^{[1
]}

Mulder, H ^{[1
]}

机构：

[1] Univ Lund Hosp, Dept Physiol & Neurosci, Sect Neuroendocrine Cell Biol, S-22185 Lund, Sweden

来源：

NEUROREPORT | 1998年 / 9卷 / 12期

关键词：

Freund's complete adjuvant; gene expression; in situ hybridization; monarthritis; neuropeptide; PACAP; sensory neurons;

D O I：

10.1097/00001756-199808240-00027

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced inflammation in the rat paw. At 12 h and day 3, but not day 21, the percentage of neurons expressing PACAP mRNA was greater in the innervating L5 DRG. Similarly, PACAP mRNA expression in individual neurons was higher in the innervating L5 DRG at 12 h and day 3, but not day 21. Up-regulated PACAP expression following adjuvant injection suggests a role for PACAP in inflammation. (C) 1998 Lippincott Williams & Wilkins.

引用

页码：2833 / 2836

页数：4

共 26 条

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