Targeting Cancer with Phytochemicals via Their Fine Tuning of the Cell Survival Signaling Pathways

被引：76

作者：

Chirumbolo, Salvatore ^{[1
,2
]}

Bjorklund, Geir ^{[2
]}

Lysiuk, Roman ^{[3
]}

Vella, Antonio ^{[4
]}

Lenchyk, Larysa ^{[5
]}

Upyr, Taras ^{[6
]}

机构：

[1] Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy

[2] Council Nutr & Environm Med CONEM, N-8610 Mo I Rana, Norway

[3] DanyloHalytskyLviv Natl Med Univ, Dept Pharmacognosy & Bot, UA-79007 Lvov, Ukraine

[4] Univ Hosp, AOUI Verona, Immunol Sect, I-37134 Verona, Italy

[5] Natl Univ Pharm, Dept Chem Nat Cpds, UA-61168 Kharkov, Ukraine

[6] Natl Univ Pharm, Dept Pharmacognosy, UA-61168 Kharkov, Ukraine

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 11期

关键词：

phytochemicals; flavonoids; cancer; mitochondria; apoptosis; EPITHELIAL-MESENCHYMAL TRANSITION; FATTY-ACID SYNTHASE; INDUCED APOPTOSIS; DOWN-REGULATION; MITOCHONDRIAL DYSFUNCTION; HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS; LUNG-CANCER; ENDOPLASMIC-RETICULUM; DEPENDENT APOPTOSIS;

D O I：

10.3390/ijms19113568

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The role of phytochemicals as potential prodrugs or therapeutic substances against tumors has come in the spotlight in the very recent years, thanks to the huge mass of encouraging and promising results of the in vitro activity of many phenolic compounds from plant raw extracts against many cancer cell lines. Little but important evidence can be retrieved from the clinical and nutritional scientific literature, where flavonoids are investigated as major pro-apoptotic and anti-metastatic compounds. However, the actual role of these compounds in cancer is still far to be fully elucidated. Many of these phytochemicals act in a pleiotropic and poorly specific manner, but, more importantly, they are able to tune the reactive oxygen species (ROS) signaling to activate a survival or a pro-autophagic and pro-apoptosis mechanism, depending on the oxidative stress-responsive endowment of the targeted cell. This review will try to focus on this issue.

引用

页数：24

共 211 条

[71] Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer [J].