Pd-Catalyzed solvent-controlled site-selective arene C-H monoacyloxylation of pyrrolo[2,3-d]pyrimidine derivatives

被引：8

作者：

Mao, Zhengtong ^{[1
]}

Liu, Min ^{[1
]}

Qian, Hongjie ^{[1
]}

Jiang, Yunfeng ^{[1
]}

Zhang, Xingxian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 39期

基金：

中国国家自然科学基金;

关键词：

ORTHO-ALKOXYLATION; ACETOXYLATION; ACYLOXYLATION; SULFONYLATION; C(SP(2))-H; ESTERS;

D O I：

10.1039/d1ob01486b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and highly regioselective Pd-catalyzed direct arene C(sp(2))-H acyloxylation of pyrrolo[2,3-d]pyrimidine derivatives is reported. The key strategy involves the utilization of the unique reactivity of pyrrolo[2,3-d]pyrimidine and the employment of pyrrolo[2,3-d]pyrimidine as the directing group. A variety of monoacyloxylated pyrrolo[2,3-d]pyrimidine derivatives can be achieved by switching the solvents under mild conditions, and they can be further modified and exhibit various biological activities.

引用

页码：8591 / 8596

页数：6