Germline stem cell aging in the Drosophila ovary

被引:7
作者
Ishibashi, Julien Roy [1 ]
Taslim, Tommy Henry [1 ]
Ruohola-Baker, Hannele [1 ]
机构
[1] Univ Washington, Dept Biochem, Inst Stem Cell & Regenerat Med, 850 Republican St, Seattle, WA 98109 USA
关键词
NICHES; REJUVENATION; MECHANISMS; INSIGHTS; PATHWAY;
D O I
10.1016/j.cois.2019.11.003
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The age-related decline of adult stem cells leads to loss of tissue homeostasis and contributes to organismal aging. Though the phenotypic hallmarks of aging are well-characterized at the organ or tissue level, the molecular processes that govern stem cell aging remain unclear. This review seeks to highlight recent research in stem cell aging in the Drosophila ovary and connect the discoveries in the fly to ongoing questions in stem cell aging.
引用
收藏
页码:57 / 62
页数:6
相关论文
共 46 条
[1]  
[Anonymous], [No title captured]
[2]  
[Anonymous], [No title captured]
[3]  
[Anonymous], [No title captured]
[4]   Loss of foxo rescues stem cell aging in Drosophila germ line [J].
Artoni, Filippo ;
Kreipke, Rebecca E. ;
Palmeira, Ondina ;
Dixon, Connor ;
Goldberg, Zachary ;
Ruohola-Baker, Hannele .
ELIFE, 2017, 6
[5]   Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish [J].
Carneiro, Madalena C. ;
Henriques, Catarina M. ;
Nabais, Joana ;
Ferreira, Tania ;
Carvalho, Tania ;
Ferreira, Miguel Godinho .
PLOS GENETICS, 2016, 12 (01)
[6]   Rejuvenation of aged progenitor cells by exposure to a young systemic environment [J].
Conboy, IM ;
Conboy, MJ ;
Wagers, AJ ;
Girma, ER ;
Weissman, IL ;
Rando, TA .
NATURE, 2005, 433 (7027) :760-764
[7]   Efficient Expression of Genes in the Drosophila Germline Using a UAS Promoter Free of Interference by Hsp70 piRNAs [J].
DeLuca, Steven Z. ;
Spradling, Allan C. .
GENETICS, 2018, 209 (02) :381-387
[8]   Stem Cells, Their Niches and the Systemic Environment: An Aging Network [J].
Drummond-Barbosa, Daniela .
GENETICS, 2008, 180 (04) :1787-1797
[9]   Zebrafish (Danio rerio) as a model for the study of aging and exercise: Physical ability and trainability decrease with age [J].
Gilbert, Matthew J. H. ;
Zerulla, Tanja C. ;
Tierney, Keith B. .
EXPERIMENTAL GERONTOLOGY, 2014, 50 :106-113
[10]   Dynamic heterogeneity as a strategy of stem cell self-renewal [J].
Greulich, Philip ;
Simons, Benjamin D. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (27) :7509-7514