The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

被引：643
作者：
Spits, Hergen [1 ]
Di Santo, James P. [2 ,3 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 AZ Amsterdam, Netherlands
[2] Inst Pasteur, Innate Immun Unit, Paris, France
[3] Inst Natl Sante & Rech Med, U668, Paris, France
来源：
NATURE IMMUNOLOGY | 2011年 / 12卷 / 01期
关键词：
NATURAL-KILLER-CELL; ROR-GAMMA-T; INDUCER CELLS; NK CELLS; TRANS-PRESENTATION; INTERFERON-GAMMA; INTERLEUKIN; 22; DIFFERENTIATION; CYTOKINE; EXPRESSION;
D O I：
10.1038/ni.1962
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Research has identified what can be considered a family of innate lymphoid cells (ILCs) that includes not only natural killer (NK) cells and lymphoid tissue-inducer (LTi) cells but also cells that produce interleukin 5 (IL-5), IL-13, IL-17 and/or IL-22. These ILC subsets are developmentally related, requiring expression of the transcriptional repressor Id2 and cytokine signals through the common gamma-chain of the IL-2 receptor. The functional differentiation of ILC subsets is orchestrated by distinct transcription factors. Analogous to helper T cell subsets, these evolutionarily conserved yet distinct ILCs seem to have important roles in protective immunity, and their dysregulation can promote immune pathology.
引用
收藏
页码：21 / 27
页数：7
相关论文
共 84 条
  • [21] Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    Fallon, PG
    Ballantyne, SJ
    Mangan, NE
    Barlow, JL
    Dasvarma, A
    Hewett, DR
    McIlgorm, A
    Jolin, HE
    McKenzie, ANJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (04) : 1105 - 1116
  • [22] Regulation of human NK-cell cytokine and chemokine production by target cell recognition
    Fauriat, Cyril
    Long, Eric O.
    Ljunggren, Hans-Gustaf
    Bryceson, Yenan T.
    [J]. BLOOD, 2010, 115 (11) : 2167 - 2176
  • [23] IL-25 induces IL-4 IL-5, and IL-13 and Th2-associated pathologies in vivo
    Fort, MM
    Cheung, J
    Yen, D
    Li, J
    Zurawski, SM
    Lo, S
    Menon, S
    Clifford, T
    Hunte, B
    Lesley, R
    Muchamuel, T
    Hurst, SD
    Zurawski, G
    Leach, MW
    Gorman, DM
    Rennick, DM
    [J]. IMMUNITY, 2001, 15 (06) : 985 - 995
  • [24] Evidence for discrete stages of human natural killer cell differentiation in vivo
    Freud, AG
    Yokohama, A
    Becknell, B
    Lee, MT
    Mao, HYC
    Ferketich, AK
    Caligiuri, MA
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (04) : 1033 - 1043
  • [25] A human CD34(+) subset resides in lymph nodes and differentiates into CD56bright natural killer cells
    Freud, AG
    Becknell, B
    Roychowdhury, S
    Mao, HC
    Ferketich, AK
    Nuovo, GJ
    Hughes, TL
    Marburger, TB
    Sung, J
    Baiocchi, RA
    Guimond, M
    Caligiuri, MA
    [J]. IMMUNITY, 2005, 22 (03) : 295 - 304
  • [26] The basic leucine zipper transcription factor E4BP4 is essential for natural killer cell development
    Gascoyne, Duncan M.
    Long, Elaine
    Veiga-Fernandes, Henrique
    de Boer, Jasper
    Williams, Owen
    Seddon, Benedict
    Coles, Mark
    Kioussis, Dimitris
    Brady, Hugh J. M.
    [J]. NATURE IMMUNOLOGY, 2009, 10 (10) : 1118 - U99
  • [27] The activating receptor NKp46 is essential for the development of type 1 diabetes
    Gur, Chamutal
    Porgador, Angel
    Elboim, Moran
    Gazit, Roi
    Mizrahi, Saar
    Stern-Ginossar, Noam
    Achdout, Hagit
    Ghadially, Hormas
    Dor, Yuval
    Nir, Tomer
    Doviner, Victoria
    Hershkovitz, Oren
    Mendelson, Michal
    Naparstek, Yaakov
    Mandelboim, Ofer
    [J]. NATURE IMMUNOLOGY, 2010, 11 (02) : 121 - U37
  • [28] Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hamada, H
    Hiroi, T
    Nishiyama, Y
    Takahashi, H
    Masunaga, Y
    Hachimura, S
    Kaminogawa, S
    Takahashi-Iwanaga, H
    Iwanaga, T
    Kiyono, H
    Yamamoto, H
    Ishikawa, H
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (01) : 57 - 64
  • [29] Functional subsets of mouse natural killer cells
    Hayakawa, Yoshihiro
    Huntington, Nicholas D.
    Nutt, Stephen L.
    Smyth, Mark J.
    [J]. IMMUNOLOGICAL REVIEWS, 2006, 214 : 47 - 55
  • [30] Inhibition of T cell and promotion of natural killer cell development by the dominant negative helix loop helix factor Id3
    Heemskerk, MHM
    Blom, B
    Nolan, G
    Stegmann, APA
    Bakker, AQ
    Weijer, K
    Res, PCM
    Spits, H
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (09) : 1597 - 1602
123456789