Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium

被引：37

作者：

Cannioto, Rikki A. ^{[1
]}

LaMonte, Michael J. ^{[2
]}

Kelemen, Linda E. ^{[3
]}

Risch, Harvey A. ^{[4
]}

Eng, Kevin H. ^{[5
]}

Minlikeeva, Albina N. ^{[1
,2
]}

Hong, Chi-Chen ^{[1
]}

Szender, J. Brian ^{[6
]}

Sucheston-Campbell, Lara ^{[1
]}

Joseph, Janine M. ^{[1
]}

Berchuck, Andrew ^{[7
]}

Chang-Claude, Jenny ^{[8
,9
]}

Cramer, Daniel W. ^{[10
,11
]}

DeFazio, Anna ^{[12
,13
]}

Diergaarde, Brenda ^{[14
]}

Doerk, Thilo ^{[15
]}

Doherty, Jennifer A. ^{[16
]}

Edwards, Robert P. ^{[17
,18
,19
]}

Fridley, Brooke L. ^{[20
]}

Friel, Grace ^{[21
]}

Goode, Ellen L. ^{[22
]}

Goodman, Marc T. ^{[23
]}

Hillemanns, Peter ^{[24
,25
]}

Hogdall, Estrid ^{[26
,27
]}

Hosono, Satoyo ^{[28
]}

Kelley, Joseph L. ^{[17
]}

Kjaer, Susanne K. ^{[26
,29
]}

Klapdor, Ruediger ^{[24
,25
]}

Matsuo, Keitaro ^{[30
]}

Odunsi, Kunle ^{[6
]}

Nagle, Christina M. ^{[31
]}

Olsen, Catherine M. ^{[31
]}

Paddock, Lisa E. ^{[32
]}

Pearce, Celeste L. ^{[33
]}

Pike, Malcolm C. ^{[34
]}

Rossing, Mary A. ^{[35
]}

Schmalfeldt, Barbara ^{[36
]}

Segal, Brahm H. ^{[37
,38
]}

Szamreta, Elizabeth A. ^{[39
]}

Thompson, Pamela J. ^{[23
]}

Tseng, Chiu-Chen ^{[40
]}

Vierkant, Robert ^{[41
]}

Schildkraut, Joellen M. ^{[42
]}

Wentzensen, Nicolas ^{[43
]}

Wicklund, Kristine G. ^{[35
]}

Winham, Stacey J. ^{[41
]}

Wu, Anna H. ^{[40
]}

Modugno, Francesmary ^{[14
,17
,18
,19
]}

Ness, Roberta B. ^{[44
]}

Jensen, Allan ^{[26
]}

机构：

[1] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[2] Univ Buffalo, Dept Epidemiol & Environm Hlth, Buffalo, NY USA

[3] Med Univ S Carolina, Dept Publ Hlth Sci, Charleston, SC USA

[4] Yale Sch Publ Hlth, Dept Chron Dis Epidemiol, New Haven, CT USA

[5] Roswell Pk Canc Inst, Dept Biostat & Bioinformat, Buffalo, NY 14263 USA

[6] Roswell Pk Canc Inst, Dept Gynecol Oncol, Buffalo, NY 14263 USA

[7] Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA

[8] German Canc Res Ctr, Div Canc Epidemiol, Unit Genet Epidemiol, Heidelberg, Germany

[9] Univ Med Ctr Hamburg Eppendorf, UCCH, Hamburg, Germany

[10] Brigham & Womens Hosp, Obstet & Gynecol Epidemiol Ctr, 75 Francis St, Boston, MA 02115 USA

[11] Harvard Med Sch, Boston, MA USA

[12] Univ Sydney, Westmead Hosp, Dept Gynecol Oncol, Sydney, NSW, Australia

[13] Univ Sydney, Westmead Inst Med Res, Sydney, NSW, Australia

[14] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA

[15] Hannover Med Sch, Gynecol Res Unit, Hannover, Germany

[16] Dartmouth Med, Geisel Sch Med, Dept Epidemiol, Hanover, NH USA

[17] Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA USA

[18] Magee Womens Res Inst, Ovarian Canc Ctr Excellence, Womens Canc Res Program, Pittsburgh, PA USA

[19] Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA

[20] Univ Kansas, Med Ctr, Biostat & Informat Shared Resource, Kansas City, KS 66103 USA

[21] Independent Hlth, Buffalo, NY USA

[22] Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA

[23] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, Los Angeles, CA 90048 USA

[24] Hannover Med Sch, Clin Gynaecol, Hannover, Germany

[25] Hannover Med Sch, Clin Obstet, Hannover, Germany

[26] Danish Canc Soc Res Ctr, Dept Virus Lifestyle & Genes, Copenhagen, Denmark

[27] Univ Copenhagen, Herlev Hosp, Dept Pathol, Mol Unit, Copenhagen, Denmark

[28] Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, Japan

[29] Univ Copenhagen, Rigshosp, Dept Gynaecol, Copenhagen, Denmark

[30] Aichi Canc Ctr Res Inst, Div Mol Med, Nagoya, Aichi, Japan

[31] QIMR Berghofer Med Res Inst, Populat Hlth Dept, Brisbane, Qld, Australia

[32] Rutgers Canc Inst New Jersey, New Jersey State Canc Registry, New Brunswick, NJ USA

[33] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[34] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[35] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA

[36] Univ Med Ctr Hamburg Eppendorf UKE, Dept Gynecol, Hamburg, Germany

[37] Roswell Pk Canc Inst, Dept Immunol, Buffalo, NY 14263 USA

[38] Roswell Pk Canc Inst, Dept Med, Buffalo, NY 14263 USA

[39] Rutgers Canc Inst New Jersey, Canc Prevent & Control, New Brunswick, NJ USA

[40] Univ Southern Calif, Norris Comprehens Canc Ctr, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA

[41] Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN USA

[42] Univ Virginia, Sch Med, Dept Publ Hlth Sci, Charlottesville, VA 22908 USA

[43] NCI, Div Canc Epidemiol & Genet, Clin Genet Branch, Bethesda, MD 20892 USA

[44] Univ Texas Sch Publ Hlth, Houston, TX USA

来源：

BRITISH JOURNAL OF CANCER | 2016年 / 115卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

recreational physical activity; inactivity; epithelial ovarian cancer; mortality risk; survival; HORMONE-THERAPY; RISK; POLYMORPHISMS; SURVIVAL;

D O I：

10.1038/bjc.2016.153

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Little is known about modifiable behaviours that may be associated with epithelial ovarian cancer (EOC) survival. We conducted a pooled analysis of 12 studies from the Ovarian Cancer Association Consortium to investigate the association between pre-diagnostic physical inactivity and mortality. Methods: Participants included 6806 women with a primary diagnosis of invasive EOC. In accordance with the Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. We utilised Cox proportional hazard models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) representing the associations of inactivity with mortality censored at 5 years. Results: In multivariate analysis, inactive women had significantly higher mortality risks, with (HR = 1.34, 95% CI: 1.18-1.52) and without (HR = 1.22, 95% CI: 1.12-1.33) further adjustment for residual disease, respectively. Conclusion: In this large pooled analysis, lack of recreational physical activity was associated with increased mortality among women with invasive EOC.

引用

页码：95 / 101

页数：7

共 34 条

[21] Genetic Variation in TYMS in the One-Carbon Transfer Pathway Is Associated with Ovarian Carcinoma Types in the Ovarian Cancer Association Consortium
Kelemen, Linda E.
Goodman, Marc T.
McGuire, Valerie
Rossing, Mary Anne
Webb, Penelope M.
Koebel, Martin
Anton-Culver, Hoda
Beesley, Jonathan
Berchuck, Andrew
Brar, Sony
Carney, Michael E.
Chang-Claude, Jenny
Chenevix-Trench, Georgia
Cramer, Daniel W.
Cunningham, Julie M.
DiCioccio, Richard A.
Doherty, Jennifer A.
Easton, Douglas F.
Fredericksen, Zachary S.
Fridley, Brooke L.
Gates, Margaret A.
Gayther, Simon A.
Gentry-Maharaj, Aleksandra
Hogdall, Estrid
Kjaer, Susanne Krueger
Lurie, Galina
Menon, Usha
Moorman, Patricia G.
Moysich, Kirsten
Ness, Roberta B.
Palmieri, Rachel T.
Pearce, Celeste L.
Pharoah, Paul D. P.
Ramus, Susan J.
Song, Honglin
Stram, Daniel O.
Tworoger, Shelley S.
Van Den Berg, David
Vierkant, Robert A.
Wang-Gohrke, Shan
Whittemore, Alice S.
Wilkens, Lynne R.
Wu, Anna H.
Schildkraut, Joellen M.
Sellers, Thomas A.
Goode, Ellen L.
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2010, 19 (07) : 1822 - 1830
[22] The dose-response effect of physical activity on cancer mortality: findings from 71 prospective cohort studies
Li, Tingting
Wei, Shaozhong
Shi, Yun
Pang, Shuo
Qin, Qin
Yin, Jieyun
Deng, Yunte
Chen, Qiongrong
Wei, Sheng
Nie, Shaofa
Liu, Li
[J]. BRITISH JOURNAL OF SPORTS MEDICINE, 2016, 50 (06) : 339 - 345
[23] Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drugs, or Acetaminophen and Risk of Ovarian Cancer
Lo-Ciganic, Wei-Hsuan
Zgibor, Janice C.
Bunker, Clareann H.
Moysich, Kirsten B.
Edwards, Robert P.
Ness, Roberta B.
[J]. EPIDEMIOLOGY, 2012, 23 (02) : 311 - 319
[24] SIMULATION STUDY OF CONFOUNDER-SELECTION STRATEGIES
MALDONADO, G
GREENLAND, S
[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1993, 138 (11) : 923 - 936
[25] Mechanisms linking physical activity with cancer
McTiernan, Anne
[J]. NATURE REVIEWS CANCER, 2008, 8 (03) : 205 - 211
[26] Talcum powder, chronic pelvic inflammation and NSAIDs in relation to risk of epithelial ovarian cancer
Merritt, Melissa A.
Green, Adele C.
Nagle, Christina M.
Webb, Penelope M.
[J]. INTERNATIONAL JOURNAL OF CANCER, 2008, 122 (01) : 170 - 176
[27] PGR +331 A/G and increased risk of epithelial ovarian cancer
Risch, Harvey A.
Bale, Allen E.
Beck, Patricia A.
Zheng, Wenxin
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (09) : 1738 - 1741
[28] Menopausal hormone therapy and risk of epithelial ovarian cancer
Rossing, Mary Anne
Cushing-Haugen, Kara L.
Wicklund, Kristine G.
Doherty, Jennifer A.
Weiss, Noel S.
[J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2007, 16 (12) : 2548 - 2556
[29] Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis
Sanchis-Gomar, Fabian
Lucia, Alejandro
Yvert, Thomas
Ruiz-Casado, Ana
Pareja-Galeano, Helios
Santos-Lozano, Alejandro
Fiuza-Luces, Carmen
Garatachea, Nuria
Lippi, Giuseppe
Bouchard, Claude
Berger, Nathan A.
[J]. CANCER PREVENTION RESEARCH, 2015, 8 (02) : 105 - 110
[30] Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer risk
Terry, KL
De Vivo, I
Titus-Ernstoff, L
Shih, MC
Cramer, DW
[J]. CANCER RESEARCH, 2005, 65 (13) : 5974 - 5981

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