Coupling multi-physics models to cardiac mechanics

被引：142

作者：

Nordsletten, D. A. ^{[1
]}

Niederer, S. A. ^{[1
]}

Nash, M. P. ^{[2
,3
]}

Hunter, P. J. ^{[2
]}

Smith, N. P. ^{[1
]}

机构：

[1] Univ Oxford, Comp Lab, Oxford OX1 3QD, England

[2] Univ Auckland, Auckland Bioengn Inst, Auckland 1, New Zealand

[3] Univ Auckland, Dept Engn Sci, Auckland 1, New Zealand

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2011年 / 104卷 / 1-3期

关键词：

Large deformation mechanics; Multi-physics modelling; Cardiac mechanics; LEFT-VENTRICULAR WALL; FLUID-STRUCTURE INTERACTION; CANINE LEFT-VENTRICLE; CORONARY BLOOD-FLOW; MYOCARDIAL FIBER ORIENTATION; FINITE-ELEMENT-METHOD; ELECTROMECHANICAL MODEL; BOUNDARY-CONDITIONS; LAMINAR STRUCTURE; STRESS-ANALYSIS;

D O I：

10.1016/j.pbiomolbio.2009.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We outline and review the mathematical framework for representing mechanical deformation and contraction of the cardiac ventricles, and how this behaviour integrates with other processes crucial for understanding and modelling heart function. Building on general conservation principles of space, mass and momentum, we introduce an arbitrary Eulerian-Lagrangian framework governing the behaviour of both fluid and solid components. Exploiting the natural alignment of cardiac mechanical properties with the tissue microstructure, finite deformation measures and myocardial constitutive relations are referred to embedded structural axes. Coupling approaches for solving this large deformation mechanics framework with three dimensional fluid flow, coronary hemodynamics and electrical activation are described. We also discuss the potential of cardiac mechanics modelling for clinical applications. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：77 / 88

页数：12

共 122 条

[31] FINITE-ELEMENT STRESS-ANALYSIS OF LEFT-VENTRICULAR MECHANICS IN THE BEATING DOG HEART [J].

GUCCIONE, JM ;

COSTA, KD ;

MCCULLOCH, AD .

JOURNAL OF BIOMECHANICS, 1995, 28 (10) :1167-1177

[32] Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging [J].

Helm, P ;

Beg, MF ;

Miller, MI ;

Winslow, RL .

COMMUNICATIVE CARDIAC CELL, 2005, 1047 :296-307

[33] Parameterization of left ventricular wall motion for detection of regional ischemia [J].

Herz, SL ;

Ingrassia, CM ;

Homma, S ;

Costa, KD ;

Holmes, JW .

ANNALS OF BIOMEDICAL ENGINEERING, 2005, 33 (07) :912-919

[34] NONLINEAR INCOMPRESSIBLE FINITE-ELEMENT FOR SIMULATING LOADING OF CARDIAC TISSUE .2. 3 DIMENSIONAL FORMULATION FOR THICK VENTRICULAR WALL SEGMENTS [J].

HOROWITZ, A ;

SHEINMAN, I ;

LANIR, Y .

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1988, 110 (01) :62-68

[35] VISCOUS-FLOW WITH LARGE FREE-SURFACE MOTION [J].

HUERTA, A ;

LIU, WK .

COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING, 1988, 69 (03) :277-324

[36] DETERMINATION OF A CONSTITUTIVE RELATION FOR PASSIVE MYOCARDIUM .1. A NEW FUNCTIONAL FORM [J].

HUMPHREY, JD ;

STRUMPF, RK ;

YIN, FCP .

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 1990, 112 (03) :333-339

[37]

Hunter P.J., 1975, Progress Biophys Molec Biol, V30, P99

[38] Modelling the mechanical properties of cardiac muscle [J].

Hunter, PJ ;

McCulloch, AD ;

ter Keurs, HEDJ .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1998, 69 (2-3) :289-331

[39] Integration from proteins to organs: the Physiome Project [J].

Hunter, PJ ;

Borg, TK .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (03) :237-243

[40] A hybrid one-dimensional/Womersley model of pulsatile blood flow in the entire coronary arterial tree [J].

Huo, Yunlong ;

Kassab, Ghassan S. .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 292 (06) :H2623-H2633

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