Coupling multi-physics models to cardiac mechanics

被引：142

作者：

Nordsletten, D. A. ^{[1
]}

Niederer, S. A. ^{[1
]}

Nash, M. P. ^{[2
,3
]}

Hunter, P. J. ^{[2
]}

Smith, N. P. ^{[1
]}

机构：

[1] Univ Oxford, Comp Lab, Oxford OX1 3QD, England

[2] Univ Auckland, Auckland Bioengn Inst, Auckland 1, New Zealand

[3] Univ Auckland, Dept Engn Sci, Auckland 1, New Zealand

来源：

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY | 2011年 / 104卷 / 1-3期

关键词：

Large deformation mechanics; Multi-physics modelling; Cardiac mechanics; LEFT-VENTRICULAR WALL; FLUID-STRUCTURE INTERACTION; CANINE LEFT-VENTRICLE; CORONARY BLOOD-FLOW; MYOCARDIAL FIBER ORIENTATION; FINITE-ELEMENT-METHOD; ELECTROMECHANICAL MODEL; BOUNDARY-CONDITIONS; LAMINAR STRUCTURE; STRESS-ANALYSIS;

D O I：

10.1016/j.pbiomolbio.2009.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We outline and review the mathematical framework for representing mechanical deformation and contraction of the cardiac ventricles, and how this behaviour integrates with other processes crucial for understanding and modelling heart function. Building on general conservation principles of space, mass and momentum, we introduce an arbitrary Eulerian-Lagrangian framework governing the behaviour of both fluid and solid components. Exploiting the natural alignment of cardiac mechanical properties with the tissue microstructure, finite deformation measures and myocardial constitutive relations are referred to embedded structural axes. Coupling approaches for solving this large deformation mechanics framework with three dimensional fluid flow, coronary hemodynamics and electrical activation are described. We also discuss the potential of cardiac mechanics modelling for clinical applications. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：77 / 88

页数：12

共 122 条

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