Antimicrobial bisabolane-type sesquiterpenoids from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330

One new aromatic bisabolene-type sesquiterpenoid (1), along with four known analogues (2-5) were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. Their structures were elucidated by NMR, HRESIMS, X-ray crystallographic analysis, and quantum chemical ECD calculations as well as comparison of those data with literature data. Compounds 1-5 were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2 and 5 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Aeromonas hydrophilia, Escherichia coli, Edwardsiella tarda and Vibrio harveyi, with the MIC values ranging from 1.0 to 8.0 mu g/mL.