Non-invasive optical biosensor for probing cell signaling

被引：61
作者：
Fang, Ye [1 ]
机构：
[1] Corning Inc, Biochem Technol Sci & Technol Div, Corning, NY 14831 USA
来源：
SENSORS | 2007年 / 7卷 / 10期
关键词：
optical biosensor; resonant waveguide grating biosensor; cell signaling; G protein-coupled receptor; dynamic mass redistribution;
D O I：
10.3390/s7102316
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Cell signaling mediated through a cellular target is encoded by spatial and temporal dynamics of downstream signaling networks. The coupling of temporal dynamics with spatial gradients of signaling activities guides cellular responses upon stimulation. Monitoring the integration of cell signaling in real time, if realized, would provide a new dimension for understanding cell biology and physiology. Optical biosensors including resonant waveguide grating (RWG) biosensor manifest a physiologically relevant and integrated cellular response related to dynamic redistribution of cellular matters, thus providing a non-invasive means for cell signaling study. This paper reviews recent progresses in biosensor instrumentation, and theoretical considerations and potential applications of optical biosensors for whole cell sensing.
引用
收藏
页码：2316 / 2329
页数：14
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