Relationship between thalliuraa-201 myocardial SPECT and findings of endomyocardial biopsy specimens in dilated cardiomyopathy

被引：5

作者：

Watanabe, M ^{[1
]}

Gotoh, K ^{[1
]}

Nagashima, K ^{[1
]}

Uno, Y ^{[1
]}

Noda, T ^{[1
]}

Nishigaki, K ^{[1
]}

Takemura, G ^{[1
]}

Kanoh, M ^{[1
]}

Yasuda, N ^{[1
]}

Ohno, Y ^{[1
]}

Minatoguchi, S ^{[1
]}

Fujiwara, H ^{[1
]}

机构：

[1] Gifu Univ, Sch Med, Dept Internal Med 2, Gifu 5008705, Japan

来源：

ANNALS OF NUCLEAR MEDICINE | 2001年 / 15卷 / 01期

关键词：

thallium; endomyocardial biopsy; dilated cardiomyopathy;

D O I：

10.1007/BF03012125

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of this study was to clarify which myocardial histological findings associated with dilated cardiomyopathy (DCM) are reflected in quantitative Tl-201 myocardial SPECT. We obtained studied SPECT images from 21 patients with DCM 10 minutes and 2 hours after they received an injection of 111 MBq Tl-201 at rest. We calculated the percent coefficient of variation of myocardial Tl-201 counts [%CV(Tl)], the washout rate (WR), standard deviation of WR [SD(WR)], extent score (ES) and severity score (SS). We used image analysis to measure % fibrosis, % myocytes, the ratio of fibrous tissue to myocyte tissue (F/My), myocyte size and standard deviation of myocyte size [SD(My)] in left ventricular endomyocardial biopsy specimens. The %CV(Tl) was correlated with % fibrosis and F/My. The ES and SS also correlated with F/My. The correlation between SD(WR) and SD(My) was significant. The present findings suggest that %CV(Tl), ES and SS of rest Tl-201 SPECT reflect myocardial fibrosis and that the standard deviation of washout reflects the distribution of myocyte size.

引用

页码：13 / 19

页数：7

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