CYP2B6 and OPRM1 gene variations predict methadone-related deaths

被引：43

作者：

Bunten, Hannah ^{[1
]}

Liang, Wei-Jun ^{[1
]}

Pounder, Derrick ^{[2
]}

Seneviratne, Collin ^{[2
]}

Osselton, Michael David ^{[1
]}

机构：

[1] Bournemouth Univ, Ctr Forens Sci, Poole BH12 5BB, Dorset, England

[2] Univ Dundee, Ctr Forens & Legal Med, Dundee DD1 4HN, Scotland

来源：

ADDICTION BIOLOGY | 2011年 / 16卷 / 01期

关键词：

CYP2B6; fatalities; metabolism; methadone; OPRM1; pharmacogenomics; PLASMA-LEVELS; PHARMACOKINETICS; POLYMORPHISMS; GENOTYPES; CHANNEL;

D O I：

10.1111/j.1369-1600.2010.00274.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The largest proportion of methadone-associated deaths occurs during the drug induction phase. We analysed methadone-related fatalities for gene variations linked with methadone action. A significant association between high methadone concentrations and the CYP2B6*6 allele characteristic of the slow metabolizer phenotype was identified. We suggest that the risk of methadone fatality may be predetermined in part by the CYP2B6*6 allele. A significant correlation was also observed between post-mortem benzodiazepine concentrations and the OPRM1 A118G allele GA in methadone-related fatalities. Screening for these susceptibility variations prior to methadone prescription could assist in reducing the potential for serious adverse effects.

引用

页码：142 / 144

页数：3

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