What is the best salvage therapy for treatment of isolated CNS relapse in elderly patients with imatinib-responsive Ph+ ALL?

被引：1

作者：

Mele, Giuseppe ^{[1
]}

Pinna, Salvatore ^{[1
]}

Melpignano, Angela ^{[1
]}

Romano, Antonio ^{[1
]}

Brocca, Maurizio Claudio ^{[1
]}

Coppi, Maria Rosaria ^{[1
]}

Quarta, Giovanni ^{[1
]}

机构：

[1] Antonio Perrino Hosp, Clin Div Haematol, BMT Unit, Brindisi, Italy

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 10期

关键词：

imatinib; Ph+ ALL; elderly patients; meningeal leukaemia;

D O I：

10.1016/j.leukres.2007.03.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of an elderly patient affected by Philadelphia positive Acute Lymphoblastic Leukaemia (Ph+ ALL) who developed meningeal leukaemia during imatinib monotherapy, despite bone marrow molecular remission. Aggressive central nervous system (CNS)-directed therapy in combination with continued imatinib treatment might be, at the moment, the most effective salvage therapy for imatinib-responsive elderly patients with isolated CNS relapse. In view of the inefficacy of imatinib at preventing meningeal leukaemia for its poor penetration into the CNS, CNS prophylactic therapy should always be an integral part of any imatinib-based treatment strategy for Ph+ ALL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1445 / 1447

页数：3

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