The role of reactive oxygen species and oxidative stress in environmental carcinogenesis and biomarker development

被引：214

作者：

Ziech, Dominique ^{[1
]}

Franco, Rodrigo ^{[2
,3
]}

Georgakilas, Alexandros G. ^{[4
]}

Georgakila, Stavroula ^{[4
]}

Malamou-Mitsi, Vasiliki ^{[5
]}

Schoneveld, Onard ^{[6
]}

Pappa, Aglaia ^{[5
,7
]}

Panayiotidis, Mihalis I. ^{[5
,8
]}

机构：

[1] Univ Nevada, Nevada Ctr Eth & Hlth Policy, Reno, NV 89557 USA

[2] Univ Nebraska, Redox Biol Ctr, Lincoln, NE 68583 USA

[3] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA

[4] E Carolina Univ, Dept Biol, Thomas Harriot Coll Arts & Sci, Greenville, NC 27858 USA

[5] Univ Ioannina, Sch Med, Dept Pathol, GR-45110 Ioannina, Greece

[6] Univ Med Ctr Utrecht, NL-3584 CX Utrecht, Netherlands

[7] Democritus Univ Thrace, Dept Mol Biol &Genet, Alexandroupolis 68100, Greece

[8] Univ Nevada, Sch Community Hlth Sci, Reno, NV 89557 USA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2010年 / 188卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ROS; Oxidative stress; Environmental carcinogenesis; Biomarkers; Oxidative DNA damage; CLUSTERED DNA LESIONS; BREAST-CANCER CELLS; MOLECULAR EPIDEMIOLOGY; AIR-POLLUTION; DAMAGE; REPAIR; INFLAMMATION; MECHANISMS; INDUCTION; EXPOSURE;

D O I：

10.1016/j.cbi.2010.07.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although we have greatly benefited from the use of traditional epidemiological approaches in linking environmental exposure to human disease, we are still lacking knowledge in to how such exposure participates in disease development. However, molecular epidemiological studies have provided us with evidence linking oxidative stress with the pathogenesis of human disease and in particular carcinogenesis. To this end, oxidative stress-based biomarkers have proved to be essential in revealing how oxidative stress may be mediating toxicity induced by many known carcinogenic environmental agents. Therefore, throughout this review article, we aim to address the current state of oxidative stress-based biomarker development with major emphasis pertaining to biomarkers of DNA, lipid and protein oxidation. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：334 / 339

页数：6

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