Fast-Acting Black-Phosphorus-Assisted Depression Therapy with Low Toxicity

被引：101
作者：
Jin, Liguo [1 ,2 ]
Hu, Ping [3 ]
Wang, Yinyin [2 ]
Wu, Luojia [2 ]
Qin, Kang [2 ]
Cheng, Haoxin [1 ,2 ]
Wang, Shuhua [1 ]
Pan, Bingxing [4 ]
Xin, Hongbo [2 ]
Zhang, Wenhua [4 ]
Wang, Xiaolei [1 ,2 ]
机构：
[1] Nanchang Univ, Coll Chem, Nanchang 330088, Jiangxi, Peoples R China
[2] Nanchang Univ, Inst Translat Med, Natl Engn Res Ctr Bioengn Drugs & Technol, Nanchang 330088, Jiangxi, Peoples R China
[3] Nanchang Univ, Inst Translat Med, Ctr Biotechnol & Biopharmaceut, Nanchang 330031, Jiangxi, Peoples R China
[4] Nanchang Univ, Inst Life Sci, Lab Fear & Anxiety Disorders, Nanchang 330031, Jiangxi, Peoples R China
来源：
ADVANCED MATERIALS | 2020年 / 32卷 / 02期
基金：
中国国家自然科学基金;
关键词：
black phosphorus; depression; fluoxetine; near-infrared light; photothermal therapy; NANOPARTICLES;
D O I：
10.1002/adma.201906050
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A black phosphorus (BP)-nanosheet-based drug-delivery system containing a therapeutic drug (Fluoxetine, Flu) is synthesized. According to subsequent behavioral, biochemical, and electrophysiological analysis, BP-Flu, after irradiated with near-infrared light (808 nm), can significantly reduce the therapy time of depression. Meanwhile, the inherent biotoxicity of Flu is also alleviated.
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页数：8
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