Enhanced Fluorescence Imaging and Photodynamic Cancer Therapy Using Hollow Mesoporous Nanocontainers

被引：9

作者：

Hong, Suk Ho ^{[1
]}

Kim, Hyunjin ^{[1
]}

Choi, Yongdoo ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, 323 Ilsan Ro, Goyang Si 10408, Gyeonggi Do, South Korea

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2017年 / 12卷 / 14期

基金：

新加坡国家研究基金会;

关键词：

fluorescence imaging; hollow mesoporous silica nanoparticles; photodynamic therapy; quenching; talaporfin sodium; SILICA NANOPARTICLES; PHOTOSENSITIZERS; DELIVERY;

D O I：

10.1002/asia.201700371

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we show that off-on type of photodynamic therapy agents could be developed using hollow mesoporous silica nanoparticles (HMSNPs), which can be used not only for enhancing delivery of photosensitizers to cancer cells but also for enabling switchable optical properties of the photosensitizers. Fluorescence and singlet oxygen generation of the photosensitizer-loaded HMSNP are turned off in its native state. In vitro cell studies showed that this HMSNP-based off-on agent may have potential utility in selective fluorescence detection and photodynamic therapy of cancers.

引用

页码：1700 / 1703

页数：4

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