Flavonoids from Anoectochilus annamensis and their Anti-inflammatory Activity

被引：1
作者：
Tran Minh Hoi [1 ]
Tran Van Thai [2 ]
Chu Thi Thu Ha [1 ]
Ha Thi Van Anh [1 ]
Phan Xuan Binh Minh [3 ]
Nguyen Tien Dat [2 ]
机构：
[1] VAST, IEBR, 18-Hoang Quoc Viet, Hanoi, Vietnam
[2] VAST, Inst Marine Biochem IMBC, Dept Bioact Prod, 18-Hoang Quoc Viet, Hanoi, Vietnam
[3] Natl Ctr Technol Progress, Ctr Expt Biol, C6 Thanh Xuan Bac, Hanoi, Vietnam
来源：
NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 05期
关键词：
Anoectochilus annamensis; Annamflavone; Flavone; Anti-inflammatory; CELLS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
One new flavonol diglycoside, 4',5-dihydroxy-3,3',7-trimethoxyflavone 4'-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (1), and two known compounds (2-3) were isolated from the methanolic extract of Anoectochilus annamensis Aver. aerial parts. The effects were evaluated of all isolated compounds (1-3) on LPS-induced production of the inflammatory mediator nitric oxide (NO) by RAW264.7 cells. 4',5-Dihydroxy-3,3',7-trimethoxyflavone (2) was the most active while the addition of a rutinoside at C-4' (compound 1) decreased the inhibitory activity. This is the first report on the chemical composition and biological activity of A. annamensis.
引用
收藏
页码：613 / 614
页数：2
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