Flavonoids from Anoectochilus annamensis and their Anti-inflammatory Activity

被引：0

作者：

Tran Minh Hoi ^{[1
]}

Tran Van Thai ^{[2
]}

Chu Thi Thu Ha ^{[1
]}

Ha Thi Van Anh ^{[1
]}

Phan Xuan Binh Minh ^{[3
]}

Nguyen Tien Dat ^{[2
]}

机构：

[1] VAST, IEBR, 18-Hoang Quoc Viet, Hanoi, Vietnam

[2] VAST, Inst Marine Biochem IMBC, Dept Bioact Prod, 18-Hoang Quoc Viet, Hanoi, Vietnam

[3] Natl Ctr Technol Progress, Ctr Expt Biol, C6 Thanh Xuan Bac, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2016年 / 11卷 / 05期

关键词：

Anoectochilus annamensis; Annamflavone; Flavone; Anti-inflammatory; CELLS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

One new flavonol diglycoside, 4',5-dihydroxy-3,3',7-trimethoxyflavone 4'-O-alpha-L-rhamnopyranosyl-(1 -> 6)-beta-D-glucopyranoside (1), and two known compounds (2-3) were isolated from the methanolic extract of Anoectochilus annamensis Aver. aerial parts. The effects were evaluated of all isolated compounds (1-3) on LPS-induced production of the inflammatory mediator nitric oxide (NO) by RAW264.7 cells. 4',5-Dihydroxy-3,3',7-trimethoxyflavone (2) was the most active while the addition of a rutinoside at C-4' (compound 1) decreased the inhibitory activity. This is the first report on the chemical composition and biological activity of A. annamensis.

引用

页码：613 / 614

页数：2

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