The polymorphism at position-174 of the IL-6 gene is not associated with inflammatory bowel disease

被引:34
作者
Klein, W [1 ]
Tromm, A [1 ]
Griga, T [1 ]
Fricke, H [1 ]
Folwaczny, C [1 ]
Hocke, M [1 ]
Eitner, K [1 ]
Marx, M [1 ]
Epplen, JT [1 ]
机构
[1] Ruhr Univ Bochum, Abt Mol Humangenet, D-44780 Bochum, Germany
关键词
genetics; inflammatory bowel disease; interleukin; 6; polymorphisms; predisposition; RFLP analysis;
D O I
10.1097/00042737-200101000-00008
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective Inflammatory bower diseases (IBD) are multifactorial disorders, characterized by failure to limit the inflammatory response to luminal antigens, Genetic factors play an important role in the pathogenesis, but little is known about the accountable genes, Increased secretion of pro-inflammatory cytokines appears crucial in the initiation of the inflammatory response, Methods To evaluate the role of the IL-6 gene in IBD, a functionally relevant polymorphism in the promoter region (G/C at position -174) has been genotyped in 169 patients with Crohn's disease (CD), 133 patients with ulcerative colitis (UC) and 440 healthy controls by using restriction fragment length polymorphism (RFLP) analysis, Results No significant differences were apparent in the allele, genotype and carrier frequencies between patients and controls. Conclusion High secretion of IL-6 does not seem to play a major role in the genetic predisposition to IBD, for I Gastroenterol Hepatol 13:45-47 (C) 2001 Lippincott Williams & Wilkins.
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页码:45 / 47
页数:3
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