Magnetic Resonance Metabolomics of Intact Tissue: A Biotechnological Tool in Cancer Diagnostics and Treatment Evaluation

被引：81
作者：
Bathen, Tone F. [1 ]
Sitter, Beathe [1 ]
Sjobakk, Torill E. [1 ]
Tessem, May-Britt [1 ]
Gribbestad, Ingrid S. [1 ]
机构：
[1] Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, MR Ctr, N-7491 Trondheim, Norway
来源：
CANCER RESEARCH | 2010年 / 70卷 / 17期
关键词：
HR-MAS SPECTROSCOPY; ANGLE-SPINNING MRS; BREAST-CANCER; H-1-NMR SPECTROSCOPY; PROSTATE TISSUES; H-1; METABOLITES; PREDICTION; SIGNATURES; APOPTOSIS;
D O I：
10.1158/0008-5472.CAN-10-0437
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Personalized medicine is increasingly important in cancer treatment for its role in staging and its potential to improve stratification of patients. Different types of molecules, genes, proteins, and metabolites are being extensively explored as potential biomarkers. This review discusses the major findings and potential of tissue metabolites determined by high-resolution magic angle spinning magnetic resonance spectroscopy for cancer detection, characterization, and treatment monitoring. Cancer Res; 70(17); 6692-6. (C)2010 AACR.
引用
收藏
页码：6692 / 6696
页数：5
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